Fig. 4
From: Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex
Candidate trans-eQTLs identify novel SCZ risk genes and biological pathways. A The numbers of SCZ GWS loci annotated by cis- and candidate trans-eQTLs. SCZ cis-eGenes do not overlap with SCZ trans-eGenes. B Trans-eGenes that colocalize with SCZ risk genes exhibit greater network centrality. C Cellular expression profiles of SCZ-associated cis- and trans-eGenes. D A SCZ GWS locus colocalizes with candidate trans-eQTLs for CENPX (left). This GWS locus is a cis-eQTL for RPS17, a cis-mediator of CENPX (right)