Stroke + TIA | Stroke | CVD | Statin medication | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GENE | Variant | Consequence | Pheno | PWES+WGS | PGWAS | OR | P | OR | P | OR | P | OR | P |
DEFT1P | rs797006828 | splice donor | VLDLPL XL | 1.2×10−6 | |||||||||
SBDS | rs113993993 | splice donor | apoC-III | 5.9×10−6 | 0.19 | 1.04 | 0.62 | 1.04 | 0.60 | 0.99 | 0.81 | 1.03 | 0.51 |
SBDS | rs113993991 | stop gain | apoC-III | 0.55 | |||||||||
LIPC | rs121912502 | p.Ser301Phe | apoA1 | 0.35 | 0.04* | 2.01 | 0.0024 | 1.58 | 0.07 | 1.54 | 0.035 | 0.97 | 0.84 |
LIPC | rs3829462 | p.Phe368Leu | apoA1 | 0.99 | 0.02 | 1.04 | 0.18 | 1.03 | 0.33 | 1.02 | 0.40 | 1 | 0.91 |
LIPC | rs113298164 | p.Thr417Met | apoA1 | 7.8×10−8 | 0.89 | 0.93 | 0.15 | 0.98 | 0.67 | 0.97 | 0.43 | 1.02 | 0.52 |
GTF3C5 | rs189383196 | start lost, p.Met126Thr | Non-HDLC | 0.38 | 0.17 | 0.99 | 0.81 | 0.96 | 0.48 | 1.02 | 0.75 | 1.12 | 0.0058 |
GTF3C5 | rs202207045 | p.Ala382Val | Non-HDLC | 7.3×10−7 | 0.02 | 0.93 | 0.36 | 0.96 | 0.59 | 0.92 | 0.21 | 0.98 | 0.77 |
LDL Fried | 1.3×10−6 | 0.02 | |||||||||||
CHOL CL | 1.2×10−6 | 0.11 | |||||||||||
TRMT5 | rs45604437 | p.Ala456Val | VLDLPL XS | 5.8×10−4 | 0.53 | 0.9 | 0.28 | 0.73 | 0.0035 | 0.88 | 0.11 | 1.08 | 0.25 |
TRMT5 | rs115400838 | p.Ser185Cys | VLDLPL XS | 1.6×10−4 | 0.75 | 1.17 | 0.0010 | 1.21 | 6×10−4 | 1.12 | 0.012 | 1.06 | 0.12 |
RBM47 | rs564837143 | p.Ala496-Ala502del | apoC-III | 2.5×10−6 | 0.08 | 1.03 | 0.67 | 0.97 | 0.66 | 1.02 | 0.70 | 1.05 | 0.33 |
MARCHF10 | rs147046907 | p.Thr560Ile | VLDLPL XS | 1.07×10−6 | 0.76 | 1.08 | 0.30 | 1.09 | 0.32 | 0.99 | 0.89 | 0.99 | 0.87 |
MARCHF10 | rs916315847 | p.Gly143Arg | VLDLPL XS | 0.03 | |||||||||
RYR3 | rs2229119 | p.Asn898Ser | VLDLTG XS | 7.42×10−3 | 0.22 | 0.99 | 0.86 | 1.04 | 0.55 | 1.03 | 0.50 | 1.08 | 0.0300 |
RYR3 | rs200294137 | p.Ile2417Val | VLDLTG XS | 0.04 | 0.87 | 0.41 | 0.92 | 0.66 | 1.05 | 0.71 | 1.06 | 0.56 | |
RYR3 | rs61996335 | p.Pro3085Arg | VLDLTG XS | 0.03 | 0.22 | 0.92 | 0.27 | 0.86 | 0.05 | 1.02 | 0.81 | 1.04 | 0.38 |
RYR3 | rs146201205 | p.Met3641Val | VLDLTG XS | 1.39×10−3 | 0.66 | 0.98 | 0.70 | 0.97 | 0.62 | 1.01 | 0.83 | 0.94 | 0.08 |
RYR3 | rs202181075 | p.Asn3849His | VLDLTG XS | 0.01 | 0.68 | 0.97 | 0.55 | 0.96 | 0.36 | 1.04 | 0.25 | 1.08 | 0.0082 |