Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease

Table 1 Summary of recent sc/snRNA-seq and snATC-seq studies on human brain tissue from individuals with AD, with publicly available data

Study	Donors (n)	Region	Cohort(s)	Nuclei (n)	Modalities	Cell types highlighted
Mathys, Davila-Valderrain, et al. (2019) [40]	48	DLPFC	ROS, MAP	60,462	snRNA-seq	Neu, Oligo, Astro, Mic
Grubman, Chew, Ouyang, et al. (2019) [41]	12	EC	VBB	13,214	snRNA-seq	Oligo, Astr, Mic, OPC
Zhou et al. (2020) [42]	32	PFC	ROS, MAP, Knight-ADRC, BRI	112,809	snRNA-seq	Neu, Oligo, Astro, Mic, Endo
Otero-Garcia et al. (2022) [43]	8	DLPFC	Multiple cohorts	116,684	scRNA-seq	Neu
Cain, Taga, et al. (2020) [28]	24	DLPFC	ROS, MAP	168,713	snRNA-seq	Neu, Oligo, Astro, Mic, Endo
Lau et al. (2020) [44]	20	PFC	SWDBB	167,776	snRNA-seq	Neu, Oligo, Astro, Mic, Endo
Olah, Menon, et al. (2020) [29]	17	DLPFC, TC	ROS, MAP	16,242	scRNA-seq	Mic
Leng, Li, et al. (2021) [45]	10	SFG, EC	NDBB, BBAS	106,136	snRNA-seq	Neu, Oligo, Astro, Mic
Gerrits et al. (2021) [46]	18	OC, OTC	NBB-IBB	482,472	snRNA-seq	Mic, Astro, Endo, Peri
Morabito, Miyoshi, Michael, et al. (2021) [47]	18	PFC	UCI MIND	61,472	snRNA-seq, snATC-seq	Neu, Oligo, Astro, Mic
Brase et al. (2021) [48]	67	PC	Knight-ADRC, DIAN	294,114	snRNA-seq	Neu, Oligo, Astro, Mic
Yang et al. (2022) [30]	26	SFC, H	Stanford/VA/NIA ACRC	143,793	snRNA-seq	Endo, Peri, Fibro
Sadick et al. (2022) [49]	16	PFC	NYU-ADRC, UCSD-ADRC, BTRC	65,180	snRNA-seq	Oligo, Astro

Brain regions: DLPFC dorsolateral prefrontal cortex, EC entorhinal cortex, PFC prefrontal cortex, TC temporal cortex, SFG superior frontal gyrus, OC occipital cortex, OTC occipitotemporal cortex, PC parietal cortex, SFC superior frontal cortex, H hippocampus. Cohorts: ROS Religious Orders Study at Rush University, MAP Memory and Aging Project at Rush University, VBB Victorian Brain Bank at the Florey Institute of Neuroscience and Mental Health, BRI Brain Research Institute at Niigata University, SWDBB South West Dementia Brain Bank, NDBB Neurodegenerative Disease Brain Bank at University of California San Francisco, BBAS Brazilian BioBank for Aging Studies at the University of Sao Paulo, NBB-IBB NeuroBiobank of the Institute Born-Bunge, UCI MIND University of California Irvine Institute for Memory Impairments and Neurological Disorders, Knight-ADRC Knight Alzheimer Disease Research Center at Washington University, DIAN Dominantly Inherited Alzheimer Network, Stanford/VA/NIA ACRC Stanford/VA/NIA Aging Clinical Research Center, NYU-ADRC NYU Grossman School of Medicine’s Alzheimer’s Disease Research Center, UCSD-ADRC University of California San Diego Shiley-Marcos ADRC, BTRC Rhode Island Hospital’s Brain Tissue Resource Center

ISSN: 1756-994X