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Fig. 2 | Genome Medicine

Fig. 2

From: Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines

Fig. 2

DNA methylation changes in COVID-19 monocytes parallel organ damage. A Heatmap of severe COVID-19 patients with DNA methylation ordered by SOFA score, including all CpG-containing probes significantly correlated with the SOFA score (Spearman correlation coefficient rho > 0.4, p < 0.01). Clinical and treatment data of COVID-19 patients are shown above the heatmap. SOFA, IL-6 level, and days in the ICU scales are shown on the right of the panel B. Normalized methylation values from heatmap showing overall group methylation of HD. Patients with SOFA ≤ 6 are indicated as SOFA LOW; those with SOFA > 6 are indicated as SOFA HIGH. C DNA methylation levels (b-values) of selected individual CpGs (and closest genes) in hypermethylated and hypomethylated sets and their position relative to the transcription start site. D Gene ontology (GO) analysis of hypermethylated and hypomethylated DMPs, analyzed with the GREAT online tool, in which CpG annotation in the EPIC array was used as background. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

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Genome Medicine

ISSN: 1756-994X

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