Fig. 1
From: Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
Clonal evolution is influenced by the immune microenvironment. Cancer cells which can evade attack by immune cells may undergo clonal expansion (blue subclone) while others perish (green subclone). Immunotherapy may lead to an increase of immune cells infiltrating the tumour and possibly tumour clearance but often the evolving tumour can acquire further immune evasive properties (orange subclone) resulting in an incomplete response to treatment