Fig. 2

Significant protein-phenotype associations identified using cis-only study-wide pQTLs as instrumental variables. Heatmaps were generated using the analyses on the WashU cohort only. A Thirty-three proteins against 37 diseases in CSF. B Thirteen proteins against 18 diseases in the plasma. C Five proteins against eight diseases in the brain. Colors were coded by 5 bins after cutting z-normalized beta MR estimate: below − 10 as dark blue, − 10 to − 5 as dodger blue, − 5 to 0 as cadet blue1, 0 to 5 as antique white1, and 5 to 10 as gold. Phenotype categories were listed on the left side as a bar plot (neurological diseases as blue, biological traits as red, blood traits as orange, cancers as purple, non-neurological diseases as green, and other risk factors as khaki)