Fig. 6

Cross-tissue MR estimate comparisons. A Heatmaps were generated on the MR estimates given the same protein-phenotype pairs with a PP > 80% when performing colocalization. Colors were coded by 4 bins after cutting z-normalized beta MR estimate: − 10 to − 5 as dodger blue, − 5 to 0 as cadet blue1, 0 to 5 as antique white1, and 5 to 10 as gold. B Scatter plot of CSF vs plasma MR estimates on the same protein-phenotype associations. C Scatter plot of plasma vs brain MR estimates on the same protein-phenotype associations. D Scatter plot of CSF vs brain MR estimates on the same protein-phenotype associations