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Table 1 Summary of replication on MR results using study-wide cis pQTLs with WashU cohort

From: Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

Tissue

Total

Replicated

Not replicated

Novel

CSF

60

21

12

27

Plasma

23

20

2

1

Brain

8

6

1

1

  1. Replicated: p-value < 0.05 and the same direction of effect size in the prior plasma study by Zheng et al.’s 2020 full MR results; not-replicated: p-value ≥ 0.05 and/or the opposite direction of effect size in the prior plasma study; novel: protein-phenotype pairs not found in the prior plasma study
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Genome Medicine

ISSN: 1756-994X

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