Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer

Fig. 4

Calculation of gene-wise ITH. A Schematic presentation of the calculation processes of integrated heterogeneity score (IHS). B Spearman correlation between intra-tumor variability scores and clustering concordance scores. C Heatmap of the expression level of the top 10 genes with lowest and highest IHS. D The distribution of IHS of protein-coding genes. E Patient group overall ratio (PGOR) curves of genes with varying IHS. Lower PGOR indicates higher ITH. F Enrichment results of top 100 genes with lowest IHS of our cohort against ranked IHS results from other four public cohorts. G Enrichment map based on GSEA results. Blue nodes represent biological processes associated with low-ITH genes, while red nodes represent biological processes related to high-ITH genes. The thickness of edges is proportional to the overlap between the gene sets. Biological processes with similar function were grouped in cluster and labeled manually

Back to article page