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Fig. 5 | Genome Medicine

Fig. 5

From: Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer

Fig. 5

Immune heterogeneity in HCC. A The proportion of 22 CIBERSORT-based immune cell types across 75 multi-regional tumor samples. B IHS of 22 estimated cell types. C The proportion of tumors that have concordant or discordant immune profiles across different intra-tumor regions in three multi-region sequencing cohorts. D IHS of protein activity of 9 co-inhibitory immune checkpoint genes. E IHS of protein activity of 12 co-stimulatory immune checkpoint genes. Dotted lines indicate the median IHS value across 5099 proteins

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