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Table 1 Clinical characteristics of the control cases, mild and critically ill COVID-19 patients

From: Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

Controls

n=17

 Age, median years (range)

71 (63–77)

 Smoking

  Never

7 (41.2%)

  Previous

8 (47%)

  Ongoing

2 (11.8%)

Mild patients

n=11

 Age, median years (range)

74 (52–89)

COVID-19 patients treated at intensive care unit (ICU)

n=211

 Age, median years (range)

64 (19–86)

 Smoking

  Never

119 (56.4%)

  Previous

81 (38.4%)

  Ongoing

11 (5.2%)

Clinical characteristics of COVID-19 cohort treated at ICU

 History of comorbidities prior to ICU admission

  BMI, n=199, median (IQR)

28.8 (25.8, 33)

  Diabetes mellitus, n=191

57 (30%)

  Vessel diseasea, n=211

43 (20%)

  Hypertension, n=191

110 (58%)

  Pulmonary diseaseb, n=190

37 (19%)

 Measurements at admission to ICU

  SOFA, n= 167, median (IQR)

8 (6, 10)

  SAPS, n=161, median (IQR)

53 (47, 58)

  CRP, n=186, median (IQR)

151 (85, 206)

  Erythrocyte count, n=185, median (IQR)

4.39 (4, 4.73)

  Thrombocyte count, n=184, median (IQR)

214 (168, 274)

  Hemoglobin, n=190, median (IQR)

133 (122, 143)

  Eotaxin level, n=173, median (IQR)

33 (25, 46)

  P/F ratio, n=167, median (IQR)

18 (15.7, 20.9)

  pH level, n=190, median (IQR)

7.46 (7.43, 7.48)

  Oxygen saturation, n=190, median (IQR)

94.12 (92.75, 95.11)

  IL-4 level, n=173, median (IQR)

2.55 (1.83, 3.62)

  IL-5 level, n=173, median (IQR)

1 (1, 14)

 Clinical outcomes

  Days at ICU, n=211, median (IQR)

10 (5, 18)

  IMV at ICU, n=189

105 (56%)

  Dialysis during ICU treatment, n=186

23 (12%)

  Thromboembolic event during ICU stayc, n=187

27 (14%)

  Critical illnessd, n=183

32 (17%)

 WHO score, n=190

  6 - Hospitalized, no mechanical ventilation or high-flow O2

77 (41%)

  7 - Intubation and mechanical ventilation, P/F ≥ 150 or SpO2/FiO2 ≥ 200

-

  8 - IMV, P/F <150 or vasopressors

11 (5.8%)

  9 - IMV, P/F <150 and vasopressors, dialysis, or ECMO

69 (36%)

  10 - Dead

33 (17%)

  1. IQR, interquartile range; SOFA, Sequential Organ Failure Assessment score; SAPS, Simplified Acute Physiology Score; CRP, C-reactive protein; IMV, invasive mechanical ventilation
  2. aVessel disease was defined as the presence in the medical history of patients of any of the following conditions: coronary heart disease, stroke, diagnoses related to central vessels (aorta aneurysm, aorta stenosis), and diseases of peripheral vessels (intermittent claudication, skin ulcers of legs)
  3. bAsthma, COPD, lung emphysema, pulmonary carcinoma, pulmonary fibrosis, cystic fibrosis, sarcoma, chronic interstitial pulmonary disease
  4. cPulmonary embolism, deep vein thrombosis, port thrombosis, cerebral infarction, mesenteric venous thrombosis, arterial thrombosis
  5. dDiagnoses relating to the weakness after ICU treatment, neuropathy, or myopathy
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Genome Medicine

ISSN: 1756-994X

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