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Fig. 3 | Genome Medicine

Fig. 3

From: Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

Fig. 3

Mechanosensitive transcriptional regulators are activated in DN glomeruli. a Dot plot displaying the commonly changed transcriptional regulations in both single-cell and bulk RNA-seq data estimated by IPA. b Heatmap showing the activity z scores of transcription factors estimated by SCENIC. c Heatmap showing the log2FC (DN vs. Ctrl) values of MRTF transcriptional target genes in mice glomerular cells. Nonsignificant genes are shown in gray (a, c). d Immunofluorescence staining of the mouse kidney paraffin sections showing the expression and localization of MRTFA and MRTFB in control and DN glomeruli. Glomerular endothelial cells were labeled by EMCN (endomucin), podocytes were labeled by NPHS1 (Nephrin), nuclei were counterstained with HOECHST. Arrows indicate mesangial cells, which were negative for EMCN and NPHS1

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Genome Medicine

ISSN: 1756-994X

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