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Fig. 6 | Genome Medicine

Fig. 6

From: Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

Fig. 6

Mesangial cells exhibit dominant signaling networks in DN glomeruli. a Dot plot showing mesangial marker genes encoding transmembrane proteins responsible for the perception and transduction of mechanical signals. MSCs, mechanosensitive ion channels; GPCRs, G protein-coupled receptors. b Change of cell–cell interactions in all pairs of kidney cell types in DN vs. Ctrl mice. c Change of cell–cell interactions in all pairs of glomerular cell types in DN vs. Ctrl mice. d Increased cell–cell interactions for mesangial cell signaling to podocytes and glomerular endothelial cell in DN mice

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Genome Medicine

ISSN: 1756-994X

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