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Fig. 1 | Genome Medicine

Fig. 1

From: Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape

Fig. 1

Patient characteristics and study design. A Multi-regional multi-omics was performed on 29 patients. Serial and multi-regional sampling strategies shown schematically. B In total, 6 out of 29 patients were untreated and the rest were treated with ICI or in combination with TKI. TCRseq of PBMC was performed at 4 time points on therapy for a subset of patients. In addition, pathological review was performed to assign N-TIL (tumors sparsely infiltrated by TILs), S-TIL (tumors dominated by stromal TILs), and ES-TIL (tumors with substantial levels of both epithelial and stromal TILs) classes to a subset of patients

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Genome Medicine

ISSN: 1756-994X

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