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Fig. 7 | Genome Medicine

Fig. 7

From: Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape

Fig. 7

Association between immune escape and clinical outcome to checkpoint blockade. Survival analysis shows the association between gene signatures obtained in this study and clinical outcome of different independent retrospective trials. A Immune Escape and JAVELIN-like signatures are associated with PFS in patients treated Avelumab plus Axitinib in JAVELIN Renal 101 cohort. B Immune Escape signature, but not the JAVELIN-like signature, correlates with the response to atezolizumab plus bevacizumab in IMmotion151 but not JAVELIN signature. C Immune Escape signature, but not the JAVELIN-like signature, correlates with the efficacy of anti-PD1-treament in CheckMate 009, 010, 025

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Genome Medicine

ISSN: 1756-994X

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