Fig. 2
Population dynamics of GPSC12. A Time-calibrated phylogeny of GPSC12 Clade I. The horizontal axis relates the tree to dates. The magenta horizontal bars show the 95% credibility intervals for the date of each node in the phylogeny. The distribution of the Ï•OXC141 prophage is shown by the column adjacent to the tree. The largest Ï•OXC141-negative clade is annotated. B Temporal trends in the frequency of genotypes in the UK and USA, divided by assignment to clade. Clade I isolates are further subdivided by whether or not they carried a Ï•OXC141-like prophage. The vertical dashed lines show the years in which PCVs were introduced in the UK and USA. C Line plot showing the decline in the prevalence of Ï•OXC141-positive genotypes in the UK and USA GPSC12 populations following the introduction of PCVs