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Fig. 4 | Genome Medicine

Fig. 4

From: The gut microbiota in multiple sclerosis varies with disease activity

Fig. 4

Bacterial species (metagenomics species (MGS)) and bacteriome modules related to MS activity. A Bacterial species and D predicted bacteriome functional modules that are contrasted between CA and CNA treatment-naïve patients (after deconfounding for age, sex, BMI, smoking status, and fecal water content). Along is their effect size (Cliff’s Delta) in the contrasts (1) CA vs CNA, (2) CA vs HC, (3) CNA vs HC. B,C,E Distribution of bacterial species or bacteriome functional modules that are more abundant in CNA patients. P-values associated with Wilcoxon tests are displayed. F Correlation between contrasted bacterial species and fasting circulating inflammation markers in treatment-naïve patients. Only bacterial species with at least one p-value under 0.05 are displayed. Black dots denote correlations with FDR ≤ 0.1, while empty circles indicate correlation with P ≤ 0.05. The right side bars indicate the Cliff’s Delta (CD, effect size) of the feature in the CA/CNA contrast (green: more abundant in CNA; yellow: more abundant in CA). CD = Cliff’s Delta; CA = clinically active; CNA = clinically not active; HC = healthy controls; MS = multiple sclerosis patients; NS = non-significant, EDSS = expanded disability status scale; MSSS = multiple sclerosis severity score (0: at baseline; 1: after 2-year follow-up)

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