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Table 1 Clinical characteristics of included probands

From: The role of genetic testing in diagnosis and care of inherited cardiac conditions in a specialised multidisciplinary clinic

 

Definite diagnosis

Uncertain clinical diagnosis

Total cohort

Age, years

56.0 ± 16.5

46.1 ± 15.9

54.8 ± 16.7

Age at diagnosis, years

42.3 ± 16.6

36.5 ± 16.1

41.6 ± 16.6

Male sex

487 (64)

71 (56)

558 (63)

Severe phenotype

209 (27)

65 (52)

274 (31)

Sudden cardiac events

84 (11)

51 (40)

135 (15)

Heart failure

7 (< 1)

0 (0)

7 (< 1)

Transplantation

9 (1)

3 (< 1)

12 (14)

Phenotype extremes

74 (10)

8 (6)

82 (9)

Ventricular arrhythmia

30 (4)

3 (2)

33 (4)

Positive family history

247 (32)

36 (29)

283 (32)

Age at diagnosis ≤ 30 years

192 (25)

52 (41)

244 (27)

Age at diagnosis ≤ 10 years

7 (< 1)

0 (0)

7 (< 1)

Inherited cardiomyopathy

662 (87)

62 (49)

724 (82)

Inherited arrhythmia syndrome

100 (13)

24 (19)

124 (14)

Undiagnosed

0 (0)

40 (32)

40 (5)

Total

762 (86)

126 (14)

888 (100)

  1. Data are shown as mean ± standard deviation or n (%)