Table 1 Meta-analysis hits in samples of European ancestry. Results for significant (q < 0.05) gene associations from the meta-analysis of 12 cohorts of European ancestry. Genes with overlapping coding and/or regulatory regions are summarized as a single locus defined as the intersection of all included genetic regions. Overlap with single-marker association results from Michailidou et al. [10] are also shown, with new associations identified for FMNL3 and AC058822.1

chr5:56,815,574–56,971,675

ENSG00000095015

MAP3K1

4.61E − 22

8.28E − 18

Yes

ENSG00000155545

MIER3

2.81E − 06

7.22E − 03

Yes

chr1:121,167,646–121,392,822

ENSG00000188610

FAM72B

1.32E − 15

1.19E − 11

Yes

ENSG00000171943

SRGAP2C

1.01E − 14

6.07E − 11

Yes

chr11:1,852,970–1,938,706

ENSG00000130595

TNNT3

6.17E − 08

2.77E − 04

Yes

ENSG00000130592

LSP1

1.31E − 07

4.70E − 04

Yes

chr10:121,478,334–121,598,458

ENSG00000066468

FGFR2

9.48E − 07

2.84E − 03

Yes

chr12:49,636,499–49,708,165

ENSG00000161791

FMNL3

6.11E − 06

1.37E − 02

No

chr19:43,766,533–43,901,385

ENSG00000104783

KCNN4

1.12E − 05

2.03E − 02

Yes

ENSG00000159871

LYPD5

1.39E − 05

2.03E − 02

Yes

ENSG00000176222

ZNF404

2.23E − 05

2.86E − 02

Yes

chr4:53,377,839–54,295,272

ENSG00000282278

AC058822.1

1.47E − 05

2.03E − 02

No

chr4:83,459,517–83,523,348

ENSG00000163322

ABRAXAS1

1.40E − 05

2.03E − 02

Yes

chr6:26,457,904–26,476,621

ENSG00000112763

BTN2A1

1.26E − 05

2.03E − 02

Yes