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Table 1 Summary of 48 independent SNPs from the meta-analysis of GWASs in East Asian and European populations

From: Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations

Locus

Chr

SNP

Positiona

Alleleb

RAFc

OR (95% CI)d

Pd

Phete

EAS

EUR

1q25.3

1

rs6424881

182986765

C/T

0.482

0.587

1.08 (1.06, 1.10)

3.05E−14

0.530

1q41

1

rs12140604

222159150

G/C

0.204

0.223

1.09 (1.07, 1.12)

3.49E−14

0.145

3p14.1

3

rs7623129

64624426

C/T

0.455

0.534

1.06 (1.04, 1.08)

2.68E−08

0.714

3q13.2

3

rs72942485

112999560

G/A

0.948

0.991

1.16 (1.11, 1.23)

4.47E−09

0.639

3q22.2

3

rs58383609

133735742

C/A

0.592

0.853

1.07 (1.05, 1.10)

1.54E−08

0.677

4q24

4

rs1909122

106127004

T/C

0.453

0.645

1.09 (1.06, 1.12)

2.79E−11

0.097

5p13.1

5

rs72748467

40262840

T/C

0.042

0.245

1.09 (1.06, 1.12)

7.91E−10

0.735

5q31.1

5

rs519705

134462596

G/A

0.369

0.540

1.07 (1.05, 1.10)

8.04E−12

0.001

5q31.1

5

rs7729156

134507139

T/C

0.305

0.447

1.09 (1.06, 1.11)

1.40E−15

0.411

5q32

5

rs2302274

149546426

G/A

0.596

0.459

1.06 (1.04, 1.08)

1.93E−09

0.839

6p21.33

6

rs2071590

31539768

G/A

0.759

0.626

1.06 (1.04, 1.08)

1.68E−08

0.033

7p12.3

7

rs6948177

47510741

G/A

0.895

0.668

1.06 (1.04, 1.09)

3.98E−08

0.932

7p13

7

rs7810512

45150331

A/C

0.744

0.747

1.07 (1.05, 1.09)

9.87E−09

0.301

8q23.3

8

rs2450114

117623719

A/G

0.146

0.115

1.09 (1.06, 1.12)

1.46E−08

0.003

8q23.3

8

rs2015069

117639532

T/C

0.582

0.859

1.09 (1.06, 1.12)

5.65E−12

0.458

8q23.3

8

rs28668628

117679601

C/T

0.013

0.113

1.12 (1.07, 1.16)

2.12E−08

0.629

8q24.21

8

rs79122086

128397907

G/T

0.203

0.123

1.12 (1.08, 1.16)

1.43E−08

0.009

8q24.21

8

rs6470510

128429660

T/C

0.158

0.187

1.11 (1.09, 1.14)

5.02E−17

0.032

9p21.3

9

rs1537372

22103183

G/T

0.482

0.581

1.07 (1.05, 1.10)

1.28E−12

0.104

10p14

10

rs827385

8705799

T/A

0.635

0.632

1.10 (1.08, 1.12)

7.23E−18

0.001

10q22.3

10

rs704017

80819132

G/A

0.279

0.540

1.12 (1.08, 1.15)

3.67E−13

0.597

10q24.2

10

rs17578367

101344167

A/G

0.179

0.198

1.07 (1.05, 1.10)

2.39E−08

0.887

10q25.2

10

rs12241008

114280702

C/T

0.300

0.094

1.14 (1.11, 1.17)

5.36E−21

0.683

10q25.2

10

rs11196170

114722621

A/G

0.682

0.255

1.07 (1.04, 1.09)

3.19E−08

0.013

11q12.2

11

rs174598

61621194

G/A

0.432

0.643

1.06 (1.04, 1.09)

2.27E−08

0.236

11q13.4

11

rs11236148

74264335

G/A

0.923

0.915

1.10 (1.07, 1.14)

3.52E−08

0.243

11q13.4

11

rs4944913

74321349

A/G

0.680

0.662

1.08 (1.06, 1.11)

2.17E−13

0.885

11q13.4

11

rs6592590

74381029

T/C

0.352

0.406

1.06 (1.04, 1.08)

4.57E−08

0.180

12p13.32

12

rs3217840

4394877

T/C

0.963

0.604

1.08 (1.05, 1.10)

1.50E−09

0.108

12q12

12

rs908664

43133634

C/A

0.607

0.508

1.06 (1.04, 1.08)

1.24E−09

0.700

12q13.12

12

rs11169572

51216890

C/T

0.263

0.381

1.07 (1.05, 1.09)

9.99E−11

0.285

12q24.21

12

rs9634162

115098094

A/G

0.536

0.500

1.06 (1.04, 1.08)

3.29E−08

0.625

14q22.1

14

rs8023022

51366863

T/C

0.456

0.209

1.07 (1.05, 1.09)

1.84E−09

0.727

14q22.2

14

rs17563

54417522

A/G

0.714

0.430

1.06 (1.04, 1.08)

9.30E−09

0.260

15q13.3

15

rs1406389

33009478

T/A

0.716

0.209

1.12 (1.08, 1.15)

1.32E−13

0.186

16q23.2

16

rs12921341

80040583

G/T

0.590

0.468

1.06 (1.04, 1.08)

4.43E−08

0.885

18q21.1

18

rs6507874

46448805

T/C

0.310

0.530

1.15 (1.13, 1.18)

2.66E−36

0.471

18q21.1

18

rs2337107

46459323

T/C

0.328

0.464

1.08 (1.06, 1.10)

1.82E−14

0.036

19q13.11

19

rs73039434

33524919

T/G

0.799

0.945

1.11 (1.07, 1.15)

1.16E−08

0.483

19q13.43

19

rs2305122

59056752

C/G

0.057

0.230

1.10 (1.07, 1.13)

4.66E−10

0.326

20p12.3

20

rs355529

6374388

T/A

0.126

0.300

1.10 (1.08, 1.13)

1.00E−15

0.186

20p12.3

20

rs1015563

6690101

T/C

0.301

0.317

1.09 (1.06, 1.11)

1.14E−14

0.710

20p12.3

20

rs6086208

7765463

T/C

0.330

0.266

1.10 (1.07, 1.12)

3.82E−17

0.015

20p12.3

20

rs2294304

7877079

A/G

0.574

0.989

1.11 (1.08, 1.15)

2.10E−10

0.521

20q13.13

20

rs6066825

47340117

A/G

0.711

0.642

1.07 (1.05, 1.10)

3.41E−11

0.758

20q13.13

20

rs6063515

49056905

G/A

0.478

0.596

1.07 (1.05, 1.10)

2.07E−08

0.438

20q13.13

20

rs6067417

48983697

C/T

0.758

0.579

1.06 (1.04, 1.09)

4.76E−09

0.117

20q13.33

20

rs6121558

60961365

T/C

0.852

0.749

1.11 (1.08, 1.14)

2.16E−13

0.186

  1. EAS East Asian population, EUR European population, OR odds ratio, 95% CI 95% confidence interval, GWAS genome-wide association study, SNP single nucleotide polymorphism
  2. aChromosomal position, hg19/GRCh37 build
  3. bRisk/reference allele
  4. cRisk allele frequency from the 1000 Genomes Project (phase 3) used in this study
  5. dMeta-analysis of GWASs in EAS and EUR populations
  6. eP value for heterogeneity test