Table 2 Main mapped genes differentially expressed in PTB, infant disease, and breast cancer
Genes mapped to risk loci | Overlapped no. with the reported PTB datasets | No. of DEGs detected in gene expression data | ||||||
|---|---|---|---|---|---|---|---|---|
Maternal PTB | Infant PTB | Infant BPD | Infant sepsis | Breast cancer ER, PR | Breast cancer TNBC | Breast cancer HER2+ | ||
ICAM1 | 6 | 1(up) | 2(up) | 1(up) | 1(up) | 1(up),2(down) | 2(up) | 1(up) |
CRHBP | 5 | 2(up) | 1(up) | 1(up) | ||||
OXTR | 5 | 2(up) | 1(up) | 1(down) | ||||
THBS4 | 3 | 1(down) | 1(down) | 1(up) | 1(up) | 2(down) | 1(up),1(down) | |
EGR2 | 2 | 1(up) | 1(up) | 1(up) | 1(up) | 2(down) | 2(down) | |
CNTLN | 1 | 1(up) | 1(up),1(down) | 1(up) | 1(down) | 1(down) | ||
MBL2 | 4 | 1(up) | ||||||
EMR1 | 2 | 1(up) | ||||||
PLAGL1 | 1 | 1(up) | 2(up) | 1(up) | 2(down) | 2(down) | 2(down) | |
DKK1 | 2(up) | 1(up) | 1(down) | 2(down) | 3(up),1(down) | 1(up),1(down) | ||
GCNT4 | 1(down) | 2(down) | 1(down) | 2(down) | 1(up),2(down) | 1(down) | 1(down) | |
DNMT1 | 1(up) | 1(up) | 1(up) | 1(up) | ||||
PIN1 | 1(down) | 1(down) | ||||||