Fig. 3
From: TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation
Soluble TREM2 species inhibit long-term potentiation (LTP). Electrophysiology analysis of LTP in C57BL/6J mice brain slices incubated with soluble TREM2 species at 15 ng/ml. A–C Incubations with sTREM2H157, sTREM2222, and sTREM2219, respectively. For each isoform, a time course with the average fESP slopes (% baseline) is shown with an arrow that indicates the time of stimulation (left panel) accompanied by a representative fEPSP trace (middle panel) and the quantification of the last 10 min of fESP slope measurements (% baseline) (right panel). A Fifteen recordings from 10 animals for control and 13 recordings from 6 animals for sTREM2H157. B, C Seven recordings from 6 animals for both control and proteins. Statistical analysis was performed by the Mann-Whitney tests for sTREM2H157 and sTREM2222 and the Student t-test for sTREM2219. Data are expressed as mean values ± SEM (**P < 0.01; ***P < 0.001)