Fig. 1
From: Influence network model uncovers relations between biological processes and mutational signatures
Gene-Signature Network (GSN). A GSN is a weighted-directed network consisting of two types of nodes: genes (green circles), and MutStates (orange ovals) corresponding to signatures. Edges of a GSN represent inferred influences and might be either positive (red) or negative (blue). B Edges of a GSN are inferred based on the activities of nodes (gene expression for genes and signature exposures for MutStates (top panel)). A directed edge from a gene to a MutState represents a putative influence from the gene to the MutState. Analogously, a directed edge from a MutState to a gene represents an inferred effect of the MutState on the gene. The thickness of the arrows reflects the edge weights