Fig. 4
From: Identification of specific susceptibility loci for the early-onset colorectal cancer
The ROC curve for the PRS predicted models. Two ROC curves for the distinct PRS logistic models weighted the effects of 86 previous GWAS-identified susceptibility loci and GWAS loci combined with EOCRC-specific risk variants, respectively, A in the GECCO cohort and B in the UK Biobank cohort. Blue line: the predicted models constructed with PRS previous GWAS-identified susceptibility loci; red line: the predicted models with PRS previous GWAS-identified susceptibility loci combined with EOCRC-specific risk variants. AUC and the point in the ROC curve identifying the best probability cutoff value (according to the Youden index) were presented. C Density plots of the PRSCRC and D PRSEOCRC+CRC for 1490 EOCRC cases (< 50 years) and 19,951 healthy controls in the GECCO cohort