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Fig. 3 | Genome Medicine

Fig. 3

From: A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

Fig. 3

Immunohistochemistry identifies immune-hot and immune-altered paediatric tumours. a Representative IHC images for CD45, CD8 and CD4 staining in CNS and extracranial tumours illustrating positive and negative tumours. b The number (cells/mm2) of CD45+, CD8+, and CD4+ cells in CNS and extracranial tumours by IHC. Black horizontal line represents the mean. c Number of CNS and extracranial samples classified by CD8 IHC as either immune-cold, immune-altered or immune-hot. d Correlation between the absolute number of immune cells by CIBERSORTx (CSX) compared to number/mm2 of CD45+ cells by IHC. e Correlation between the absolute number of CD8 T-cells by CSX compared to number/mm2 of CD8+ T-cells by IHC. f Correlation between the absolute number of CD4 T-cells by CSX compared to number/mm2 of CD4+ cells by IHC. Blue line in (d–f) is the correlation line of best fit

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