Fig. 4
From: A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
Novel paediatric immune signature predicts T-cell infiltrated tumours. a Heatmap of the novel 15-gene paediatric immune signature (IPASS) in patients with matched IHC (n = 78). The top annotation bar represents the cancer category, the second annotation is CD8 IHC classification and the third annotation bar is the normalised IPASS score measured between 1 (green) and − 1 (orange). IPASS distribution across b CNS and c extracranial tumours. d Number of validation samples classified by CD8 IHC as either immune-cold, immune-altered or immune-hot. e IPASS for each validation sample assigned to their IHC CD8 classification (n = 26)