Fig. 5
From: A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
Immune genes and archetypes provide insight into TIME of paediatric tumours. a Heatmap of 12 immune checkpoint genes associated with IPASS in extracranial tumours (n = 148). The top annotation bar represents the cancer category, the second annotation is CD8 IHC classification and the third annotation bar is the normalised IPASS score measured between 1 (green) and − 1 (orange). Below the heatmap, the annotation bars represent the number of T-cell receptor (TCR) clones, tumour purity (percentage of malignant cells), tumour mutation burden (TMB) and neoantigen load. b, c IPASS score (highlighted by hot/altered (red) or cold (blue)) for each sample assigned to their given dominant immune archetype in b CNS and c extracranial tumours. Archetype key: dendritic cells (DC), immune stromal rich (ISR), immune rich (IR), classical DC (cDC) and immune desert (ID)