Fig. 2

Genomic characteristics. The top panel shows the mutation load for each tumour, split into clonal mutations that are found in all samples, and subclonal mutations found only in a subset. The second panel shows the fraction of each admixed sample estimated to be derived from tumour (purity), split by whether the sample was derived from a tissue sample of primary tumour (n = 1), metastasis (n = 16), patient-derived xenograft (n = 8), or cfDNA (n = 6). Only samples with an estimated tumour purity > 5% are shown. The third panel shows the different genomic events for a set of cancer genes of interest. Mutations are represented as tiles, and somatic copy number aberrations (SCNAs) are overlaid as triangles. The colour of the tiles and triangles represents the timing of the mutations and copy number events, respectively. The final panel shows the proportion of mutations attributed to different mutational signatures for each patient. The five patients on the right of the figure, which are greyed out, do not have sufficient mutations (less than 50) to perform reliable signature deconvolution