Fig. 1
From: Stalled oligodendrocyte differentiation in IDH-mutant gliomas
Declining expression of NFOL and MFOL signatures in PM gliomas from the CGGA dataset. A, B Heatmaps of differential gene expression profile between PM gliomas and NT brain tissues at the indicated p and q values with a fold change (FC) at 1.5. Genes concordantly enriched in both PM glioma subtypes (C) show upregulated expression in OPC and NFOL of mouse oligodendrocyte lineage as analyzed in GSE52564 [30] (D), and in early stages of human brain development as analyzed in GSE25219 [31] (E). F Drastically declining expression in the gene expression signatures of NFOL and MFOL in PM gliomas with (upper) or without (lower) 1p19q co-deletion. The same color codes were used in A, B, C, and F. Data shown in A to F were derived from CGGA dataset. G Percentages of the members of the indicated stage-specific signature gene sets enriched in PM gliomas from CGGA, GSE4290, and Rembrandt datasets; mean and standard deviation are shown. NT: non-tumor brain tissues, OPC: oligodendrocyte progenitor cell, COP: differentiation-committed oligodendrocyte precursors, NFOL: newly formed oligodendrocyte, MFOL: myeline-forming oligodendrocyte, MO: mature oligodendrocyte. **p < 0.01; ****p < 0.0001