Fig. 1

Multi-label CRIS classification of 596 CRC samples from TCGA. a Heatmap representing CRIS classes genes (rows) as Z-scores and classified samples (columns). Above the heatmap, a panel reports secondary classifications. b Pie chart representing the proportion of samples with unique (white) or multiple (black) class assignments by multiCRIS in the TCGA CRC dataset. c Proportions of primary and secondary assignments for each CRIS class in the TCGA dataset. d Heatmap representing the enrichment of key molecular features in primary and secondary CRIS classes; black bars indicate positivity to a molecular feature (i.e., MSI status, and BRAF/KRAS mutations); Z-scores are represented for continuous variables such as EMT, Paneth and WNT scores. ***p-value < 0.0001, **p-value < 0.001, *p-value < 0.05, ns = not significant