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Fig. 5 | Genome Medicine

Fig. 5

From: Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

Fig. 5

Cellular processes identified by gene set enrichment analysis (GSEA) of the three β-cell sub-clusters β1, β2, and β3 in the scRNA-seq and snRNA-seq integration dataset. A Dotplot depicting the expression levels and percentage of cells expressing four representative extracellular matrix (ECM)-related C2 pathway genes (interaction, response, organization, and integrins) and the corresponding enrichment plots below. B Dotplot depicting the expression levels and percentage of cells expressing four representative vesicle-related C2 pathway genes (biogenesis, budding, transport, lysosome) and the corresponding enrichment plots below. C Dotplot depicting the expression levels and percentage of cells expressing four representative insulin-related C2 pathway genes (processing, secretion, and glucose metabolism) and the corresponding enrichment plots below. D Dotplot depicting the expression levels and percentage of cells expressing four representative proliferation/differentiation related C2 pathway genes (proliferation, development, differentiation, regulation of gene expression) and the corresponding enrichment plots below

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Genome Medicine

ISSN: 1756-994X

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