Fig. 6

Transcriptomic features between primary and metastatic lesions in FH-RCC harboring NF2 mutation. A Paired ladder box plots depict the changes of signatures of tumor proliferation rate, retinoblastoma gene in cancer, G1 to S cell cycle control, and cell cycle in patient-matched cases. The above and inferior panels indicated NF2 mutation and wild-type subgroups, respectively. P-value was determined by paired t test. B The box plot of signatures of tumor proliferation rate, retinoblastoma gene in cancer, G1 to S cell cycle control, and cell cycle in NF2 mutated metastatic lesions compared to NF2 wild-type lesions. C,D Representative image of KI67 staining in patient-matched cases (FH28 and FH29), quantitative analysis was performed between NF2 mutated metastatic lesions and NF2 wild-type metastatic lesions using Ki67 index