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Fig. 1 | Genome Medicine

Fig. 1

From: Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

Fig. 1

Visium spatial transcriptomics detects spatial human tumour and mouse transcripts within medulloblastoma PDOX undissociated tissue sections. a Illustration of experimental design. Sonic hedgehog PDOX medulloblastoma (Med-1712FH) mouse models were generated by seeding tumour cells in mouse cerebellum. Mice received a 7-day course of Palbociclib and compared to untreated control tumours. H&E-stained images display regions of human tumour and mouse brain in Palbociclib-treated mice (demarcated ‘Palbociclib A’ and ‘Palbociclib B’) and controls (demarcated ‘Control C’ and ‘Control D’). Contrast-enhanced MRI shows the tumour location in PDOX mouse brain (outlined in red). Palbociclib-treated and control sections are indicated with stars and squares, respectively. b The spatial context of the human, mix and mouse spots. Spots are classified as human (green), mix (yellow) or mouse (blue) based on whether they predominantly express one species’ genes or a combination of both. PDOX patient-derived orthotopic xenograft, MRI magnetic resonance imaging

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