Table 1 SNP heritability (SNP-h2) of hearing problems assessed in the UK Biobank. Sample size (N) is reported as case/control and total sample size for binary and quantitative traits, respectively. SNP-h2 SNP-based heritability, SE standard error
From: Sex differences in the polygenic architecture of hearing problems in adults
Analysis | Trait | N | SNP-h2 | SE | SNP-h2 Z-score |
|---|---|---|---|---|---|
Sex-combined | Hearing difficulty/problems | 125,011/340,771 | 0.038 | 0.002 | 20.16 |
Hearing difficulty/problems with background noise | 183,497/292,534 | 0.050 | 0.002 | 26.11 | |
Hearing aid user | 17,754/303,823 | 0.017 | 0.002 | 9.67 | |
Speech-reception-threshold (SRT) estimate (left) | 195,188 | 0.002 | 0.002 | 0.96 | |
Speech-reception-threshold (SRT) estimate (right) | 195,916 | 0.009 | 0.002 | 3.74 | |
Hearing problem ordinal trait | 300,958 | 0.045 | 0.003 | 15.23 | |
Males | Hearing difficulty/problems | 68,781/145,768 | 0.048 | 0.003 | 15.45 |
Hearing difficulty/problems with background noise | 97,002/121,104 | 0.050 | 0.003 | 16.23 | |
Hearing aid user | 9,882/146,135 | 0.021 | 0.003 | 6.59 | |
Hearing problem ordinal trait | 147,788 | 0.051 | 0.004 | 12.73 | |
Females | Hearing difficulty/problems | 56,230/195,003 | 0.040 | 0.003 | 14.21 |
Hearing difficulty/problems with background noise | 86,495/171,430 | 0.054 | 0.003 | 18.79 | |
Hearing aid user | 7,872/157,688 | 0.017 | 0.003 | 5.55 | |
Hearing problem ordinal trait | 153,170 | 0.054 | 0.004 | 13.5 |