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Call for papers: Targeting cancer evolution in the clinic

Guest editors: Razelle Kurzrock and Alberto Bardelli

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Progress in the understanding of cancer evolution, heterogeneity, and metastasis has accelerated in recent years due in large part to advancements in sequencing technology. The advent of massively parallel sequencing has encouraged extensive tumor mutational profiling efforts, mapping of cancer genomic landscapes, and widespread tracking of genomes longitudinally from cancer development, to metastasis, and eventually to therapeutic response and resistance. 
Particularly intriguing are attempts to translate these insights into the clinic, where they can be utilized for precision medicine, from prevention, risk prediction and early detection, to therapeutic targeting, longitudinal monitoring, and prognosis. The tracking of clonal dynamics to determine driver mutations, monitor potential resistant subpopulations, and gauge response to therapy represents a promising strategy for clinical cancer medicine. 

To capture advances in this growing area, Genome Medicine is pleased to announce a call for papers for our upcoming special issue on ‘Targeting cancer evolution in the clinic', guest edited by Dr. Razelle Kurzrock from the University of San Diego and Dr. Alberto Bardelli from the University of Torino. 

We are now inviting the submission of Research, Method, Software, Database and Guideline manuscripts of outstanding interest covering the breadth of cancer evolution, heterogeneity, and metastasis as well as clinical cancer therapeutics including:

  • Clonal evolution and dynamics
  • Cancer genomes
  • Tumor heterogeneity and clonal diversity 
  • Cancer initiation and progression
  • Longitudinal monitoring 
  • Clinical trials
  • Liquid biopsies (CTCs, cfDNA, ctDNA)
  • Treatment response and clonal resistance
  • Precision medicine and therapeutics
  • Immunotherapy
  • Clonal neoantigens 
  • Metastasis and seeding 
  • Tumor microenvironment
  • Single-cell mutational profiling 
  • Multi-omics
  • Bioinformatics and computational approaches
  • Machine learning 
  • Prediction of mutational order and clone phylogenies

Extended submission deadline: 28 February 2021

To submit your manuscript, please use the Genome Medicine online submission system and indicate in your covering letter that you would like the article to be considered for the ‘Targeting cancer evolution in the clinic’ special issue. If you would like to enquire about the suitability of a manuscript for consideration, please email

This collection of articles has not been sponsored and articles will undergo the journal’s standard peer-review process. The Guest Editors declare that they have no competing interests. The Guest Editors serve an advisory role to guide the scope of the special issue and commissioned content; final editorial decisions lie with the Editor.