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  3. Obesity and type 2 diabetes (T2D) are linked both with host genetics and with environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede di...

    Authors: Moran Yassour, Mi Young Lim, Hyun Sun Yun, Timothy L. Tickle, Joohon Sung, Yun-Mi Song, Kayoung Lee, Eric A. Franzosa, Xochitl C. Morgan, Dirk Gevers, Eric S. Lander, Ramnik J. Xavier, Bruce W. Birren, GwangPyo Ko and Curtis Huttenhower
    Citation: Genome Medicine 2016 8:17
    Content type: Research Published on:

  4. Nuclease-based technologies have been developed that enable targeting of specific DNA sequences directly in the zygote. These approaches provide an opportunity to modify the genomes of inbred mice, and allow t...

    Authors: Joffrey Mianné, Lauren Chessum, Saumya Kumar, Carlos Aguilar, Gemma Codner, Marie Hutchison, Andrew Parker, Ann-Marie Mallon, Sara Wells, Michelle M. Simon, Lydia Teboul, Steve D. M. Brown and Michael R. Bowl
    Citation: Genome Medicine 2016 8:16
    Content type: Research Published on:

  5. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected...

    Authors: Hsiao-Han Chang, Janina Dordel, Tjibbe Donker, Colin J. Worby, Edward J. Feil, William P. Hanage, Stephen D. Bentley, Susan S. Huang and Marc Lipsitch
    Citation: Genome Medicine 2016 8:18
    Content type: Research Published on:

  6. Inter-tissue molecular interactions are critical to the function and behavior of biological systems in multicellular organisms, but systematic studies of interactions between tissues are lacking. Also, existin...

    Authors: Quan Long, Carmen Argmann, Sander M. Houten, Tao Huang, Siwu Peng, Yong Zhao, Zhidong Tu and Jun Zhu
    Citation: Genome Medicine 2016 8:15
    Content type: Research Published on:

  8. Genome-wide data are increasingly important in the clinical evaluation of human disease. However, the large number of variants observed in individual patients challenges the efficiency and accuracy of diagnost...

    Authors: Regis A. James, Ian M. Campbell, Edward S. Chen, Philip M. Boone, Mitchell A. Rao, Matthew N. Bainbridge, James R. Lupski, Yaping Yang, Christine M. Eng, Jennifer E. Posey and Chad A. Shaw
    Citation: Genome Medicine 2016 8:13
    Content type: Research Published on:

  10. Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and res...

    Authors: Jasreet Hundal, Beatriz M. Carreno, Allegra A. Petti, Gerald P. Linette, Obi L. Griffith, Elaine R. Mardis and Malachi Griffith
    Citation: Genome Medicine 2016 8:11
    Content type: Method Published on:

  11. Frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. Here we characterize frailty associations wi...

    Authors: Matthew A. Jackson, Ian B. Jeffery, Michelle Beaumont, Jordana T. Bell, Andrew G. Clark, Ruth E. Ley, Paul W. O’Toole, Tim D. Spector and Claire J. Steves
    Citation: Genome Medicine 2016 8:8
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2016 8:21

  13. String-of-beads polypeptides allow convenient delivery of epitope-based vaccines. The success of a polypeptide relies on efficient processing: constituent epitopes need to be recovered while avoiding neo-epito...

    Authors: Benjamin Schubert and Oliver Kohlbacher
    Citation: Genome Medicine 2016 8:9
    Content type: Method Published on:

  14. Progress in personalized medicine is now being translated to personalized nutrition. A recent proof-of-concept study shows that the increase in blood glucose levels after a meal is highly variable between indi...

    Authors: Marc-Emmanuel Dumas
    Citation: Genome Medicine 2016 8:7
    Content type: Research Highlight Published on:

  16. Alzheimer’s disease affects ~13 % of people in the United States 65 years and older, making it the most common neurodegenerative disorder. Recent work has identified roles for environmental, genetic, and epige...

    Authors: Corey T. Watson, Panos Roussos, Paras Garg, Daniel J. Ho, Nidha Azam, Pavel L. Katsel, Vahram Haroutunian and Andrew J. Sharp
    Citation: Genome Medicine 2016 8:5
    Content type: Research Published on:

  17. Bacterial whole-genome sequencing (WGS) has the potential to identify reservoirs of multidrug-resistant organisms and transmission of these pathogens across healthcare networks. We used WGS to define transmiss...

    Authors: Hayley J. Brodrick, Kathy E. Raven, Ewan M. Harrison, Beth Blane, Sandra Reuter, M. Estée Török, Julian Parkhill and Sharon J. Peacock
    Citation: Genome Medicine 2016 8:4
    Content type: Research Published on:

  18. Authors: Alexander L. Greninger, Kevin Messacar, Thelma Dunnebacke, Samia N. Naccache, Scot Federman, Jerome Bouquet, David Mirsky, Yosuke Nomura, Shigeo Yagi, Carol Glaser, Michael Vollmer, Craig A. Press, Bette K. Kleinschmidt-DeMasters, Samuel R. Dominguez and Charles Y. Chiu
    Citation: Genome Medicine 2016 8:1
    Content type: Erratum Published on:

    The original article was published in Genome Medicine 2015 7:113

  19. Large-scale cohort-based whole exome sequencing of individuals with neurodevelopmental disorders (NDDs) has identified numerous novel candidate disease genes; however, detailed phenotypic information is often ...

    Authors: Janson White, Christine R. Beck, Tamar Harel, Jennifer E. Posey, Shalini N. Jhangiani, Sha Tang, Kelly D. Farwell, Zöe Powis, Nancy J. Mendelsohn, Janice A. Baker, Lynda Pollack, Kati J. Mason, Klaas J. Wierenga, Daniel K. Arrington, Melissa Hall, Apostolos Psychogios…
    Citation: Genome Medicine 2016 8:3
    Content type: Research Published on:

  20. Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focuse...

    Authors: Stephane Bourgeois, Andrea Jorgensen, Eunice J. Zhang, Anita Hanson, Matthew S. Gillman, Suzannah Bumpstead, Cheng Hock Toh, Paula Williamson, Ann K. Daly, Farhad Kamali, Panos Deloukas and Munir Pirmohamed
    Citation: Genome Medicine 2016 8:2
    Content type: Research Published on:

  23. Hemophagocytic lymphohistiocytosis (HLH) is a rapid-onset, potentially fatal hyperinflammatory syndrome. A prompt molecular diagnosis is crucial for appropriate clinical management. Here, we validated and pros...

    Authors: Bianca Tesi, Kristina Lagerstedt-Robinson, Samuel C. C. Chiang, Eya Ben Bdira, Miguel Abboud, Burcu Belen, Omer Devecioglu, Zehra Fadoo, Allen E. J. Yeoh, Hans Christian Erichsen, Merja Möttönen, Himmet Haluk Akar, Johanna Hästbacka, Zuhre Kaya, Susana Nunes, Turkan Patiroglu…
    Citation: Genome Medicine 2015 7:130
    Content type: Research Published on:

  25. Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication followin...

    Authors: Dirk S. Paul, Allison Jones, Rob S. Sellar, Neema P. Mayor, Andrew Feber, Amy P. Webster, Neuza Afonso, Ruhena Sergeant, Richard M. Szydlo, Jane F. Apperley, Martin Widschwendter, Stephen Mackinnon, Steven G. E. Marsh, J. Alejandro Madrigal, Vardhman K. Rakyan, Karl S. Peggs…
    Citation: Genome Medicine 2015 7:128
    Content type: Research Published on:

  26. Comprehensive identification of insertions/deletions (indels) across the full size spectrum from second generation sequencing is challenging due to the relatively short read length inherent in the technology. ...

    Authors: Rendong Yang, Andrew C. Nelson, Christine Henzler, Bharat Thyagarajan and Kevin A. T. Silverstein
    Citation: Genome Medicine 2015 7:127
    Content type: Method Published on:

  27. Association studies have identified a number of loci that contribute to an increased body mass index (BMI), the strongest of which is in the first intron of the FTO gene on human chromosome 16q12.2. However, t...

    Authors: Lilian E. Hunt, Boris Noyvert, Leena Bhaw-Rosun, Abdul K. Sesay, Lavinia Paternoster, Ellen A. Nohr, George Davey Smith, Niels Tommerup, Thorkild I. A. Sørensen and Greg Elgar
    Citation: Genome Medicine 2015 7:126
    Content type: Research Published on:

  28. Primary amoebic meningoencephalitis (PAM) is a rare, often lethal, cause of encephalitis, for which early diagnosis and prompt initiation of combination antimicrobials may improve clinical outcomes.

    Authors: Alexander L. Greninger, Kevin Messacar, Thelma Dunnebacke, Samia N. Naccache, Scot Federman, Jerome Bouquet, David Mirsky, Yosuke Nomura, Shigeo Yagi, Carol Glaser, Michael Vollmer, Craig A. Press, Bette K. Kleinschmidt-DeMasters, Samuel R. Dominguez and Charles Y. Chiu
    Citation: Genome Medicine 2015 7:113
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2016 8:1

  29. Deep sequencing of recombined T cell receptor (TCR) genes and transcripts has provided a view of T cell repertoire diversity at an unprecedented resolution. Beyond profiling peripheral blood, analysis of tissu...

    Authors: Scott D. Brown, Lisa A. Raeburn and Robert A. Holt
    Citation: Genome Medicine 2015 7:125
    Content type: Method Published on:

  30. Despite the potential to produce antibodies that can neutralize different virus (heterotypic neutralization), there is no knowledge of why vaccination against influenza induces protection predominantly against...

    Authors: Bernardo Cortina-Ceballos, Elizabeth Ernestina Godoy-Lozano, Juan Téllez-Sosa, Marbella Ovilla-Muñoz, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Rosa Elena Gómez-Barreto, Humberto Valdovinos-Torres, Irma López-Martínez, Rodrigo Aparicio-Antonio, Mario H. Rodríguez and Jesús Martínez-Barnetche
    Citation: Genome Medicine 2015 7:124
    Content type: Research Published on:

  31. The adaptive immune system generates a remarkable range of antigen-specific T-cell receptors (TCRs), allowing the recognition of a diverse set of antigens. Most of this diversity is encoded in the complementar...

    Authors: Jared Dean, Ryan O. Emerson, Marissa Vignali, Anna M. Sherwood, Mark J. Rieder, Christopher S. Carlson and Harlan S. Robins
    Citation: Genome Medicine 2015 7:123
    Content type: Research Published on:

  32. Activation and differentiation of T-helper (Th) cells into Th1 and Th2 types is a complex process orchestrated by distinct gene activation programs engaging a number of genes. This process is crucial for a rob...

    Authors: Kartiek Kanduri, Subhash Tripathi, Antti Larjo, Henrik Mannerström, Ubaid Ullah, Riikka Lund, R. David Hawkins, Bing Ren, Harri Lähdesmäki and Riitta Lahesmaa
    Citation: Genome Medicine 2015 7:122
    Content type: Research Published on:

  36. Human cancer cell lines are an important resource for research and drug development. However, the available annotations of cell lines are sparse, incomplete, and distributed in multiple repositories. Re-analyz...

    Authors: Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin and John C. Castle
    Citation: Genome Medicine 2015 7:118
    Content type: Database Published on:

  41. Gene profiling of diffuse large B cell lymphoma (DLBCL) has revealed broad gene expression deregulation compared to normal B cells. While many studies have interrogated well known and annotated genes in DLBCL,...

    Authors: Akanksha Verma, Yanwen Jiang, Wei Du, Lauren Fairchild, Ari Melnick and Olivier Elemento
    Citation: Genome Medicine 2015 7:110
    Content type: Research Published on:

  42. The Cancer Genome Atlas (TCGA) project has generated genomic data sets covering over 20 malignancies. These data provide valuable insights into the underlying genetic and genomic basis of cancer. However, expl...

    Authors: HoJoon Lee, Jennifer Palm, Susan M. Grimes and Hanlee P. Ji
    Citation: Genome Medicine 2015 7:112
    Content type: Database Published on:

  44. We have previously shown that childhood-onset rheumatic diseases show aberrant patterns of gene expression that reflect pathology-associated co-expression networks. In this study, we used novel computational a...

    Authors: Nan Du, Kaiyu Jiang, Ashley D. Sawle, Mark Barton Frank, Carol A. Wallace, Aidong Zhang and James N. Jarvis
    Citation: Genome Medicine 2015 7:109
    Content type: Research Published on:

  45. Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ...

    Authors: Andrew E. Teschendorff, Shih-Han Lee, Allison Jones, Heidi Fiegl, Marie Kalwa, Wolfgang Wagner, Kantaraja Chindera, Iona Evans, Louis Dubeau, Arturo Orjalo, Hugo M. Horlings, Lukas Niederreiter, Arthur Kaser, Winnie Yang, Ellen L. Goode, Brooke L. Fridley…
    Citation: Genome Medicine 2015 7:108
    Content type: Research Published on:

  46. Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for m...

    Authors: Olga Anczuków and Adrian R. Krainer
    Citation: Genome Medicine 2015 7:107
    Content type: Research Highlight Published on:

  47. Alzheimer’s disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills. The greatest risk factor for Alzheimer’s disease is advanced age. A recent geno...

    Authors: Rita Guerreiro and Jose Bras
    Citation: Genome Medicine 2015 7:106
    Content type: Research Highlight Published on:

  48. Obesity is a multi-factorial health problem in which genetic factors play an important role. Limited results have been obtained in single-gene studies using either genomic or transcriptomic data. RNA sequencin...

    Authors: Lisette J. A. Kogelman, Daria V. Zhernakova, Harm-Jan Westra, Susanna Cirera, Merete Fredholm, Lude Franke and Haja N. Kadarmideen
    Citation: Genome Medicine 2015 7:105
    Content type: Research Published on:

  49. The use of somatic mutations for predicting clinical outcome is difficult because a mutation can indirectly influence the function of many genes, and also because clinical follow-up is sparse in the relatively...

    Authors: Lőrinc Pongor, Máté Kormos, Christos Hatzis, Lajos Pusztai, András Szabó and Balázs Győrffy
    Citation: Genome Medicine 2015 7:104
    Content type: Research Published on:

  50. The mechanisms by which genetic variants, such as single nucleotide polymorphisms (SNPs), identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which c...

    Authors: Sarah Voisin, Markus Sällman Almén, Galina Y. Zheleznyakova, Lina Lundberg, Sanaz Zarei, Sandra Castillo, Fia Ence Eriksson, Emil K. Nilsson, Matthias Blüher, Yvonne Böttcher, Peter Kovacs, Janis Klovins, Mathias Rask-Andersen and Helgi B. Schiöth
    Citation: Genome Medicine 2015 7:103
    Content type: Research Published on:
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Genome Medicine

ISSN: 1756-994X

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