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  1. The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear receptor superfamily. The PPAR family consists of three members: PPARα, PPARγ, and ...

    Authors: Lee D Roberts, David G Hassall, Deborah A Winegar, John N Haselden, Andrew W Nicholls and Julian L Griffin

    Citation: Genome Medicine 2009 1:115

    Content type: Research

    Published on:

  2. Chronic obstructive pulmonary disease (COPD) is a common problem worldwide, and it is recognized that the term encompasses overlapping sub-phenotypes of disease. The development of a sub-phenotype may be deter...

    Authors: Alice M Wood, See Ling Tan and Robert A Stockley

    Citation: Genome Medicine 2009 1:112

    Content type: Review

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  3. Genomic data often persist far beyond the initial study in which they were generated. But the true value of the data is tied to their being both used and useful, and the usefulness of the data relies intimatel...

    Authors: John Quackenbush

    Citation: Genome Medicine 2009 1:111

    Content type: Commentary

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  4. Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little...

    Authors: David G Clayton

    Citation: Genome Medicine 2009 1:110

    Content type: Review

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  5. A function for the microRNA (miRNA) pathway in vascular development and angiogenesis has been firmly established. miRNAs with selective expression in the vasculature are attractive as possible targets in miRNA...

    Authors: Erik Larsson, Peder Fredlund Fuchs, Johan Heldin, Irmeli Barkefors, Cecilia Bondjers, Guillem Genové, Christelle Arrondel, Pär Gerwins, Christine Kurschat, Bernhard Schermer, Thomas Benzing, Scott J Harvey, Johan Kreuger and Per Lindahl

    Citation: Genome Medicine 2009 1:108

    Content type: Research

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  6. The inflammatory bowel diseases, Crohn's disease and ulcerative colitis, pose a fascinating challenge to specialists in gastroenterology, infectious diseases, immunology and genetics and an often crushing burd...

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2009 1:103

    Content type: Musings

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  7. Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expect...

    Authors: Sandro J de Souza, Beatriz Stransky and Anamaria A Camargo

    Citation: Genome Medicine 2009 1:101

    Content type: Minireview

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  8. Genome-wide association studies are the most comprehensive and straightforward approach to teasing out the identity of genetic polymorphisms associated with any given disease or characteristic. With the availa...

    Authors: Bruce N Cronstein

    Citation: Genome Medicine 2009 1:98

    Content type: Minireview

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  9. Transposable elements (TEs) have been consistently underestimated in their contribution to genetic instability and human disease. TEs can cause human disease by creating insertional mutations in genes, and als...

    Authors: Victoria P Belancio, Prescott L Deininger and Astrid M Roy-Engel

    Citation: Genome Medicine 2009 1:97

    Content type: Review

    Published on:

  10. Mitochondrial disorders can originate from mutations in one of many nuclear genes controlling the organelle function or in the mitochondrial genome (mitochondrial DNA (mtDNA)). The large numbers of potential c...

    Authors: Valeria Vasta, Sarah B Ng, Emily H Turner, Jay Shendure and Si Houn Hahn

    Citation: Genome Medicine 2009 1:100

    Content type: Research

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  11. In June 2009, the Science and Technology Committee of the UK House of Lords published a report on genomic medicine, based on expert evidence collected over an 18-month period. Crucially, the report signaled th...

    Authors: Hilary Burton, Caroline F Wright and Ron Zimmern

    Citation: Genome Medicine 2009 1:93

    Content type: Commentary

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  12. Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now b...

    Authors: Gilles Clermont, Charles Auffray, Yves Moreau, David M Rocke, Daniel Dalevi, Devdatt Dubhashi, Dana R Marshall, Peter Raasch, Frank Dehne, Paolo Provero, Jesper Tegner, Bruce J Aronow, Michael A Langston and Mikael Benson

    Citation: Genome Medicine 2009 1:88

    Content type: Correspondence

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  13. Translation of research findings into clinical practice is an important aspect of medical progress. Even for the early stages of genomics, research aiming to deepen understandings of underlying mechanisms of d...

    Authors: Naomi Hawkins, Jantina de Vries, Paula Boddington, Jane Kaye and Catherine Heeney

    Citation: Genome Medicine 2009 1:87

    Content type: Correspondence

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  14. Gene patents have generally not impeded biomedical research, but some problems that arise in genetic diagnostics can be attributed to exclusively licensed gene patents. Gene patents for therapeutics have often...

    Authors: Subhashini Chandrasekharan and Robert Cook-Deegan

    Citation: Genome Medicine 2009 1:92

    Content type: Commentary

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  15. A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic u...

    Authors: Harry Campbell, Igor Rudan, Alan H Bittles and Alan F Wright

    Citation: Genome Medicine 2009 1:91

    Content type: Commentary

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  16. Recent studies have demonstrated that network approaches are highly appropriate tools for understanding the extreme complexity of the aging process. Moreover, the generality of the network concept helps to def...

    Authors: Gábor I Simkó, Dávid Gyurkó, Dániel V Veres, Tibor Nánási and Peter Csermely

    Citation: Genome Medicine 2009 1:90

    Content type: Review

    Published on:

  17. From the point of view of genome medicine, Barack Obama has made two vital policy decisions: he has chosen a new director of the National Institutes of Health, and his proposed change in United States healthca...

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2009 1:86

    Content type: Musings

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  18. The need for an integrated view of data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize how external perturbations propagate through the exp...

    Authors: Elisabet Selga, Carlota Oleaga, Sara Ramírez, M Cristina de Almagro, Véronique Noé and Carlos J Ciudad

    Citation: Genome Medicine 2009 1:83

    Content type: Research

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  19. Granulosa cell tumors (GCTs) of the ovary belong to the group of ovarian sex-cord stromal tumors and represent 5 to 10% of ovarian malignancies. GCTs exhibit several morphological, biochemical and hormonal fea...

    Authors: Nicolas Kalfa, Reiner A Veitia, Bérénice A Benayoun, Brigitte Boizet-Bonhoure and Charles Sultan

    Citation: Genome Medicine 2009 1:81

    Content type: Minireview

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  20. For almost three decades, Huntington's disease has been a prototype for the application of genetic strategies to human disease. HD, the Huntington's disease gene, was the first autosomal defect mapped using only ...

    Authors: James F Gusella and Marcy E MacDonald

    Citation: Genome Medicine 2009 1:80

    Content type: Review

    Published on:

  21. Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and...

    Authors: Cristiana Cruceanu, Martin Alda and Gustavo Turecki

    Citation: Genome Medicine 2009 1:79

    Content type: Review

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  22. Genome-wide association analyses on large patient cohorts are generating large sets of candidate disease genes. This is coupled with the availability of ever-increasing genomic databases and a rapidly expandin...

    Authors: Nicki Tiffin, Miguel A Andrade-Navarro and Carolina Perez-Iratxeta

    Citation: Genome Medicine 2009 1:77

    Content type: Review

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  23. The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk fac...

    Authors: Francisco Jesus Moron, Agustin Ruiz and Jose Jorge Galan

    Citation: Genome Medicine 2009 1:76

    Content type: Minireview

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  24. Will the routine availability of genome sequence information on individuals render family history information obsolete? I argue that it will not, both because the taking of a family history has other uses for ...

    Authors: Angus John Clarke

    Citation: Genome Medicine 2009 1:75

    Content type: Musings

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  25. Neuroblastoma is one of the most common solid tumors of childhood, arising from immature sympathetic nervous system cells. The clinical course of patients with neuroblastoma is highly variable, ranging from sp...

    Authors: Nadine Van Roy, Katleen De Preter, Jasmien Hoebeeck, Tom Van Maerken, Filip Pattyn, Pieter Mestdagh, Joëlle Vermeulen, Jo Vandesompele and Frank Speleman

    Citation: Genome Medicine 2009 1:74

    Content type: Review

    Published on:

  26. Psoriasis is recognized as a complex disease for which multiple genetic and non-genetic factors influence susceptibility. The major susceptibility locus resides in the MHC class I region and, until relatively ...

    Authors: Rhodri Ll Smith, Richard B Warren, Christopher EM Griffiths and Jane Worthington

    Citation: Genome Medicine 2009 1:72

    Content type: Review

    Published on:

  27. Medical treatment for patients has historically been based on two primary elements: the expected outcome for the patient, and the ability of treatment to improve the expected outcome. The advance in genomic te...

    Authors: Sumithra J Mandrekar and Daniel J Sargent

    Citation: Genome Medicine 2009 1:69

    Content type: Commentary

    Published on:

  28. The incidence of cancer and its associated mortality are increasing globally, indicating an urgent need to develop even more effective and sensitive sets of biomarkers that could help in early diagnosis and co...

    Authors: Mohamed SS Alhamdani, Christoph Schröder and Jörg D Hoheisel

    Citation: Genome Medicine 2009 1:68

    Content type: Review

    Published on:

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