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  1. Prion diseases share common features of neurodegenerative disorders, infectious diseases and pathologies linked to misfolded proteins. Whether these aspects are independently and fortuitously present in prion ...

    Authors: Maurizio Pocchiari, Anna Poleggi, Serena Principe, Silvia Graziano and Franco Cardone

    Citation: Genome Medicine 2009 1:63

    Content type: Review

    Published on:

  2. DNA copy number variations (CNVs) are an important component of genetic variation, affecting a greater fraction of the genome than single nucleotide polymorphisms (SNPs). The advent of high-resolution SNP arra...

    Authors: Adam Shlien and David Malkin

    Citation: Genome Medicine 2009 1:62

    Content type: Review

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  3. The message is loud and clear. MicroRNA-96, one in a cluster of three related neurosensory microRNAs, is crucial to the development and maintenance of inner ear hair cells and hearing in mice and humans. Two r...

    Authors: Michael D Weston and Garrett A Soukup

    Citation: Genome Medicine 2009 1:59

    Content type: Minireview

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  4. Advances in mass spectrometry have had a great impact on the field of proteomics. A major challenge of proteomic analysis has been the elucidation of glycan modifications of proteins in complex proteomes. Glyc...

    Authors: Allen D Taylor, William S Hancock, Marina Hincapie, Naoyuki Taniguchi and Samir M Hanash

    Citation: Genome Medicine 2009 1:57

    Content type: Review

    Published on:

  5. Myeloproliferative neoplasms (MPNs) are a group of closely related stem-cell-derived clonal proliferative diseases. Most cases are sporadic but first-degree relatives of MPN patients have a five- to seven-fold...

    Authors: Lynn R Goldin, Magnus Björkholm, Sigurdur Y Kristinsson, Jan Samuelsson and Ola Landgren

    Citation: Genome Medicine 2009 1:55

    Content type: Minireview

    Published on:

  6. Atrial fibrillation (AF) is the most common persistent cardiac dysrhythmia and the number one cause of arrhythmia-related hospitalizations. In addition, AF is a major contributor to stroke. With life expectanc...

    Authors: Samir B Damani and Eric J Topol

    Citation: Genome Medicine 2009 1:54

    Content type: Review

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  7. A 100 kb region on 9p21.3 harbors two major disease susceptibility loci: one for type 2 diabetes (T2D) and one for coronary heart disease (CHD). The single nucleotide polymorphisms (SNPs) associated with these...

    Authors: Kaisa Silander, Hua Tang, Sean Myles, Eveliina Jakkula, Nicholas J Timpson, Luigi Cavalli-Sforza and Leena Peltonen

    Citation: Genome Medicine 2009 1:51

    Content type: Correspondence

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  8. The availability of serum collections from the Women's Health Initiative (WHI) conjugated equine estrogens (CEE) randomized controlled trial provides an opportunity to test the potential of in-depth quantitati...

    Authors: Hiroyuki Katayama, Sophie Paczesny, Ross Prentice, Aaron Aragaki, Vitor M Faca, Sharon J Pitteri, Qing Zhang, Hong Wang, Melissa Silva, Jacob Kennedy, Jacques Rossouw, Rebecca Jackson, Judith Hsia, Rowan Chlebowski, JoAnn Manson and Samir Hanash

    Citation: Genome Medicine 2009 1:47

    Content type: Research

    Published on:

  9. Rhinovirus infections cause at least 70% of virus-related wheezing exacerbations and cold and flu-like illnesses. Infections are also associated with otitis media, sinusitis and pneumonia. The annual impact of...

    Authors: Katherine E Arden and Ian M Mackay

    Citation: Genome Medicine 2009 1:44

    Content type: Minireview

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  10. It is now becoming generally accepted that a significant amount of human genetic variation is due to structural changes of the genome rather than to base-pair changes in the DNA. As for base-pair changes, know...

    Authors: James R Lupski

    Citation: Genome Medicine 2009 1:42

    Content type: Opinion

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  11. Although microarray technology allows the investigation of the transcriptomic make-up of a tumor in one experiment, the transcriptome does not completely reflect the underlying biology due to alternative splic...

    Authors: Anneleen Daemen, Olivier Gevaert, Fabian Ojeda, Annelies Debucquoy, Johan AK Suykens, Christine Sempoux, Jean-Pascal Machiels, Karin Haustermans and Bart De Moor

    Citation: Genome Medicine 2009 1:39

    Content type: Research

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  12. Though the field has moved with glacial speed, gene therapies have been carried out successfully in patients with bone marrow disorders including immune deficiencies. The field may be poised to move forward mo...

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2009 1:38

    Content type: Musings

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  13. Alzheimer's disease is a progressive neurodegenerative disorder with high prevalence in old age. It is the most common cause of dementia, with a risk reaching 50% after the age of 85 years, and with the increa...

    Authors: Dimitrios Avramopoulos

    Citation: Genome Medicine 2009 1:34

    Content type: Review

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  14. Functional genomic studies are dominated by transcriptomic approaches, in part reflecting the vast amount of information that can be obtained, the ability to amplify mRNA and the availability of commercially s...

    Authors: Julian L Griffin and Christine Des Rosiers

    Citation: Genome Medicine 2009 1:32

    Content type: Review

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  15. Despite the recent success of genome-wide association studies (GWASs) in identifying loci consistently associated with coronary artery disease (CAD), a large proportion of the genetic components of CAD and its...

    Authors: Matthew B Lanktree and Robert A Hegele

    Citation: Genome Medicine 2009 1:28

    Content type: Review

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  16. Disparities in health outcomes of members of different ancestral or ethnic groups can be observed in both developed and developing countries and continue to be a global concern. Genomic medicine can help towar...

    Authors: David Gurwitz and Jeantine E Lunshof

    Citation: Genome Medicine 2009 1:24

    Content type: Commentary

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  17. The wide general publication of a putative genetic test for athletic supremacy is clearly an abuse of genetics and reveals an undercurrent of hucksterism in biomedical science.

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2009 1:18

    Content type: Musings

    Published on:

  18. The availability of personalized genomic tests, ordered directly by consumers, is rapidly growing. These tests are unlike other genetic or biochemical tests in the sheer amount of data they provide, but interp...

    Authors: David Magnus, Mildred K Cho and Robert Cook-Deegan

    Citation: Genome Medicine 2009 1:17

    Content type: Commentary

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  19. The genome era in medicine is upon us. Questions that arise from patient and family care are a watershed for research and technology, which in turn fuel the cycle of opportunity for impact through delivery of ...

    Authors: Janet A Buchanan, Andrew R Carson, David Chitayat, David Malkin, M Stephen Meyn, Peter N Ray, Cheryl Shuman, Rosanna Weksberg and Stephen W Scherer

    Citation: Genome Medicine 2009 1:16

    Content type: Editorial

    Published on:

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