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  1. Persons with schizophrenia and other psychotic disorders have a high prevalence of obesity, impaired glucose tolerance, and lipid abnormalities, particularly hypertriglyceridemia and low high-density lipoprote...

    Authors: Matej Orešič, Jing Tang, Tuulikki Seppänen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lönnqvist, Marko Sysi-Aho, Tuulia Hyötyläinen, Jonna Perälä and Jaana Suvisaari

    Citation: Genome Medicine 2011 3:19

    Content type: Research

    Published on:

  2. Plausible genome-wide associations for episodic neurological diseases (such as migraine, epilepsy and ataxias) have been slow to emerge. The first such association was reported in a recent genome-wide associat...

    Authors: Verneri Anttila, Maija Wessman, Mikko Kallela and Aarno Palotie

    Citation: Genome Medicine 2011 3:17

    Content type: Research highlight

    Published on:

  3. The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies a...

    Authors: A Cecile JW Janssens, John PA Ioannidis, Cornelia M van Duijn, Julian Little and Muin J Khoury

    Citation: Genome Medicine 2011 3:16

    Content type: Correspondence

    Published on:

  4. The gut microbiome is the term given to describe the vast collection of symbiotic microorganisms in the human gastrointestinal system and their collective interacting genomes. Recent studies have suggested tha...

    Authors: James M Kinross, Ara W Darzi and Jeremy K Nicholson

    Citation: Genome Medicine 2011 3:14

    Content type: Review

    Published on:

  5. There has been considerable interest in cancer stem cells (CSCs) among cancer biologists and clinicians, most likely because of their role in the heterogeneity of cancer and their potential application in canc...

    Authors: Bo Wang and Samson T Jacob

    Citation: Genome Medicine 2011 3:11

    Content type: Review

    Published on:

  6. The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated wi...

    Authors: Krista S Crider and Lynn B Bailey

    Citation: Genome Medicine 2011 3:9

    Content type: Commentary

    Published on:

  7. Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. HCV infection is currently treated with IFNα plus ribavirin for 24 to 48 weeks. This demanding therapy fails in up to 50% ...

    Authors: John E Tavis, Maureen J Donlin, Rajeev Aurora, Xiaofeng Fan and Adrian M Di Bisceglie

    Citation: Genome Medicine 2011 3:8

    Content type: Review

    Published on:

  8. Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated pe...

    Authors: Christian P Kratz, Gennady Bratslavsky and Jianxin Shi

    Citation: Genome Medicine 2011 3:1

    Content type: Commentary

    Published on:

  9. Multiple sclerosis (MS) is the most common cause of chronic neurologic disability beginning in early to middle adult life. Results from recent genome-wide association studies (GWAS) have substantially lengthen...

    Authors: Joanne H Wang, Derek Pappas, Philip L De Jager, Daniel Pelletier, Paul IW de Bakker, Ludwig Kappos, Chris H Polman, Lori B Chibnik, David A Hafler, Paul M Matthews, Stephen L Hauser, Sergio E Baranzini and Jorge R Oksenberg

    Citation: Genome Medicine 2011 3:3

    Content type: Research

    Published on:

  10. Cell type heterogeneity may have a substantial effect on gene expression profiling of human tissue. Several in silico methods for deconvoluting a gene expression profile into cell-type-specific subprofiles have b...

    Authors: Yingdong Zhao and Richard Simon

    Citation: Genome Medicine 2010 2:93

    Content type: Commentary

    Published on:

  11. Cystic fibrosis is one of the most common life-limiting inherited disorders. Its clinical impact manifests chiefly in the lung, pancreas, gastrointestinal tract and sweat glands, with lung disease typically be...

    Authors: Sally H Pattison and J Stuart Elborn

    Citation: Genome Medicine 2010 2:88

    Content type: Review

    Published on:

  12. Sudden infant death syndrome (SIDS) is a major contributor to postneonatal infant death, and is the third leading cause of infant mortality in the USA. While public health efforts have reduced these deaths in ...

    Authors: David W Van Norstrand and Michael J Ackerman

    Citation: Genome Medicine 2010 2:86

    Content type: Review

    Published on:

  13. Imatinib mesylate (IM), a tyrosine kinase inhibitor, is one of the first molecularly targeted therapies to have been used in the clinic. It has proven to be efficient in the treatment of chronic myeloid leukem...

    Authors: Stéphanie Dulucq and Maja Krajinovic

    Citation: Genome Medicine 2010 2:85

    Content type: Review

    Published on:

  14. A recent publication that combined rat gene expression data and a human genetic association study has identified the first genetic risk factor for chronic pain in humans. In four of the five cohorts studied, t...

    Authors: Ming Zheng and Gary Peltz

    Citation: Genome Medicine 2010 2:82

    Content type: Minireview

    Published on:

  15. Discoveries from genome-wide association studies have contributed to our knowledge of the genetic etiology of many complex diseases. However, these account for only a small fraction of each disease's heritabil...

    Authors: Nadine Melhem and Bernie Devlin

    Citation: Genome Medicine 2010 2:79

    Content type: Commentary

    Published on:

  16. Endometriosis is a gynecological disease characterized by implantation of endometrial tissue outside of the uterus. Early familial aggregation and twin studies noted a higher risk of endometriosis among relati...

    Authors: Erica C Dun, Robert N Taylor and Fritz Wieser

    Citation: Genome Medicine 2010 2:75

    Content type: Review

    Published on:

  17. A correction to: Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North, Steven R Meshnick andthe NIAID Center for HIV/AIDS Vaccine Immunology. A whole genome association study of mother...

    Authors: Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North and Steven R Meshnick

    Citation: Genome Medicine 2010 2:76

    Content type: Erratum

    Published on:

    The original article was published in Genome Medicine 2010 2:17

  18. Preimplantation genetic diagnosis (PGD) involves testing of single cells biopsied from oocytes and/or embryos generated in vitro. As only embryos unaffected for a given genetic condition are transferred to the ut...

    Authors: Martine De Rycke

    Citation: Genome Medicine 2010 2:74

    Content type: Review

    Published on:

  19. Stem cell banks are increasingly seen as an essential resource of biological materials for both basic and translational research. Stem cell banks support transnational access to quality-controlled and ethicall...

    Authors: Bartha M Knoppers and Rosario Isasi

    Citation: Genome Medicine 2010 2:73

    Content type: Review

    Published on:

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