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  1. Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now b...

    Authors: Gilles Clermont, Charles Auffray, Yves Moreau, David M Rocke, Daniel Dalevi, Devdatt Dubhashi, Dana R Marshall, Peter Raasch, Frank Dehne, Paolo Provero, Jesper Tegner, Bruce J Aronow, Michael A Langston and Mikael Benson
    Citation: Genome Medicine 2009 1:88
  2. Translation of research findings into clinical practice is an important aspect of medical progress. Even for the early stages of genomics, research aiming to deepen understandings of underlying mechanisms of d...

    Authors: Naomi Hawkins, Jantina de Vries, Paula Boddington, Jane Kaye and Catherine Heeney
    Citation: Genome Medicine 2009 1:87
  3. Gene patents have generally not impeded biomedical research, but some problems that arise in genetic diagnostics can be attributed to exclusively licensed gene patents. Gene patents for therapeutics have often...

    Authors: Subhashini Chandrasekharan and Robert Cook-Deegan
    Citation: Genome Medicine 2009 1:92
  4. A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic u...

    Authors: Harry Campbell, Igor Rudan, Alan H Bittles and Alan F Wright
    Citation: Genome Medicine 2009 1:91
  5. Recent studies have demonstrated that network approaches are highly appropriate tools for understanding the extreme complexity of the aging process. Moreover, the generality of the network concept helps to def...

    Authors: Gábor I Simkó, Dávid Gyurkó, Dániel V Veres, Tibor Nánási and Peter Csermely
    Citation: Genome Medicine 2009 1:90
  6. From the point of view of genome medicine, Barack Obama has made two vital policy decisions: he has chosen a new director of the National Institutes of Health, and his proposed change in United States healthca...

    Authors: David G Nathan and Stuart H Orkin
    Citation: Genome Medicine 2009 1:86
  7. The need for an integrated view of data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize how external perturbations propagate through the exp...

    Authors: Elisabet Selga, Carlota Oleaga, Sara Ramírez, M Cristina de Almagro, Véronique Noé and Carlos J Ciudad
    Citation: Genome Medicine 2009 1:83
  8. Granulosa cell tumors (GCTs) of the ovary belong to the group of ovarian sex-cord stromal tumors and represent 5 to 10% of ovarian malignancies. GCTs exhibit several morphological, biochemical and hormonal fea...

    Authors: Nicolas Kalfa, Reiner A Veitia, Bérénice A Benayoun, Brigitte Boizet-Bonhoure and Charles Sultan
    Citation: Genome Medicine 2009 1:81
  9. For almost three decades, Huntington's disease has been a prototype for the application of genetic strategies to human disease. HD, the Huntington's disease gene, was the first autosomal defect mapped using only ...

    Authors: James F Gusella and Marcy E MacDonald
    Citation: Genome Medicine 2009 1:80
  10. Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and...

    Authors: Cristiana Cruceanu, Martin Alda and Gustavo Turecki
    Citation: Genome Medicine 2009 1:79
  11. Genome-wide association analyses on large patient cohorts are generating large sets of candidate disease genes. This is coupled with the availability of ever-increasing genomic databases and a rapidly expandin...

    Authors: Nicki Tiffin, Miguel A Andrade-Navarro and Carolina Perez-Iratxeta
    Citation: Genome Medicine 2009 1:77
  12. The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk fac...

    Authors: Francisco Jesus Moron, Agustin Ruiz and Jose Jorge Galan
    Citation: Genome Medicine 2009 1:76
  13. Will the routine availability of genome sequence information on individuals render family history information obsolete? I argue that it will not, both because the taking of a family history has other uses for ...

    Authors: Angus John Clarke
    Citation: Genome Medicine 2009 1:75
  14. Neuroblastoma is one of the most common solid tumors of childhood, arising from immature sympathetic nervous system cells. The clinical course of patients with neuroblastoma is highly variable, ranging from sp...

    Authors: Nadine Van Roy, Katleen De Preter, Jasmien Hoebeeck, Tom Van Maerken, Filip Pattyn, Pieter Mestdagh, Joëlle Vermeulen, Jo Vandesompele and Frank Speleman
    Citation: Genome Medicine 2009 1:74
  15. Psoriasis is recognized as a complex disease for which multiple genetic and non-genetic factors influence susceptibility. The major susceptibility locus resides in the MHC class I region and, until relatively ...

    Authors: Rhodri Ll Smith, Richard B Warren, Christopher EM Griffiths and Jane Worthington
    Citation: Genome Medicine 2009 1:72
  16. Medical treatment for patients has historically been based on two primary elements: the expected outcome for the patient, and the ability of treatment to improve the expected outcome. The advance in genomic te...

    Authors: Sumithra J Mandrekar and Daniel J Sargent
    Citation: Genome Medicine 2009 1:69
  17. The incidence of cancer and its associated mortality are increasing globally, indicating an urgent need to develop even more effective and sensitive sets of biomarkers that could help in early diagnosis and co...

    Authors: Mohamed SS Alhamdani, Christoph Schröder and Jörg D Hoheisel
    Citation: Genome Medicine 2009 1:68
  18. Prion diseases share common features of neurodegenerative disorders, infectious diseases and pathologies linked to misfolded proteins. Whether these aspects are independently and fortuitously present in prion ...

    Authors: Maurizio Pocchiari, Anna Poleggi, Serena Principe, Silvia Graziano and Franco Cardone
    Citation: Genome Medicine 2009 1:63
  19. DNA copy number variations (CNVs) are an important component of genetic variation, affecting a greater fraction of the genome than single nucleotide polymorphisms (SNPs). The advent of high-resolution SNP arra...

    Authors: Adam Shlien and David Malkin
    Citation: Genome Medicine 2009 1:62
  20. The message is loud and clear. MicroRNA-96, one in a cluster of three related neurosensory microRNAs, is crucial to the development and maintenance of inner ear hair cells and hearing in mice and humans. Two r...

    Authors: Michael D Weston and Garrett A Soukup
    Citation: Genome Medicine 2009 1:59
  21. Advances in mass spectrometry have had a great impact on the field of proteomics. A major challenge of proteomic analysis has been the elucidation of glycan modifications of proteins in complex proteomes. Glyc...

    Authors: Allen D Taylor, William S Hancock, Marina Hincapie, Naoyuki Taniguchi and Samir M Hanash
    Citation: Genome Medicine 2009 1:57
  22. Myeloproliferative neoplasms (MPNs) are a group of closely related stem-cell-derived clonal proliferative diseases. Most cases are sporadic but first-degree relatives of MPN patients have a five- to seven-fold...

    Authors: Lynn R Goldin, Magnus Björkholm, Sigurdur Y Kristinsson, Jan Samuelsson and Ola Landgren
    Citation: Genome Medicine 2009 1:55
  23. Atrial fibrillation (AF) is the most common persistent cardiac dysrhythmia and the number one cause of arrhythmia-related hospitalizations. In addition, AF is a major contributor to stroke. With life expectanc...

    Authors: Samir B Damani and Eric J Topol
    Citation: Genome Medicine 2009 1:54
  24. A 100 kb region on 9p21.3 harbors two major disease susceptibility loci: one for type 2 diabetes (T2D) and one for coronary heart disease (CHD). The single nucleotide polymorphisms (SNPs) associated with these...

    Authors: Kaisa Silander, Hua Tang, Sean Myles, Eveliina Jakkula, Nicholas J Timpson, Luigi Cavalli-Sforza and Leena Peltonen
    Citation: Genome Medicine 2009 1:51
  25. The availability of serum collections from the Women's Health Initiative (WHI) conjugated equine estrogens (CEE) randomized controlled trial provides an opportunity to test the potential of in-depth quantitati...

    Authors: Hiroyuki Katayama, Sophie Paczesny, Ross Prentice, Aaron Aragaki, Vitor M Faca, Sharon J Pitteri, Qing Zhang, Hong Wang, Melissa Silva, Jacob Kennedy, Jacques Rossouw, Rebecca Jackson, Judith Hsia, Rowan Chlebowski, JoAnn Manson and Samir Hanash
    Citation: Genome Medicine 2009 1:47
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