Multiple sclerosis: major histocompatibility complexity and antigen presentation

Table 1 Examples of HLA associations with MS across the world among common alleles

HLA-DRB1allele	Associated population	Approximate odds ratio
*01	Canada, Sweden, UK, US, [8, 11, 26, 27]	0.6
*03 (17)	Canada, Sweden, UK, US, Italy, Sicily, Spain, Sardinia [8–11]	1.7
*04	Sardinia [35]	2.2
*07	Italy [7]	0.6
*08	Canada, UK, US, Italy, Sicily, Spain (15/08 genotype) [8, 10, 11]	6 (15/08 genotype)
*09	Japan [36]	0.4
*10	Italy, Canada [7, 8, 11]	2 (protective in Canadians)
*11	Canada, Malta [8, 11, 37]	0.7
*12 ^†	Canada [11]	0.9
*13	Sardinia, Israel [5, 6]	2
*14	Canada, UK, US, Italy, Sicily, Spain [8, 10, 11]	0.3
*15	Near-universal	3

^†Based on a small number of observations. The allele frequency of HLA-DRB1*16 is too low to make any definitive conclusions.

ISSN: 1756-994X