Skip to main content

Table 1 Examples of HLA associations with MS across the world among common alleles

From: Multiple sclerosis: major histocompatibility complexity and antigen presentation

HLA-DRB1allele Associated population Approximate odds ratio
*01 Canada, Sweden, UK, US, [8, 11, 26, 27] 0.6
*03 (17) Canada, Sweden, UK, US, Italy, Sicily, Spain, Sardinia [811] 1.7
*04 Sardinia [35] 2.2
*07 Italy [7] 0.6
*08 Canada, UK, US, Italy, Sicily, Spain (15/08 genotype) [8, 10, 11] 6 (15/08 genotype)
*09 Japan [36] 0.4
*10 Italy, Canada [7, 8, 11] 2 (protective in Canadians)
*11 Canada, Malta [8, 11, 37] 0.7
*12 Canada [11] 0.9
*13 Sardinia, Israel [5, 6] 2
*14 Canada, UK, US, Italy, Sicily, Spain [8, 10, 11] 0.3
*15 Near-universal 3
  1. Based on a small number of observations. The allele frequency of HLA-DRB1*16 is too low to make any definitive conclusions.