Genome Medicine

Research: Evidence-driven reporting of treatment options in molecular tumor boards

A novel standardized method reports actionable somatic variants to support clinicians in finding the clinical meaning of genomic variants

Database: Cancer Genome Interpreter annotates the relevance of tumor alterations

A versatile platform automates the interpretation of newly sequenced cancer genomes and annotates the potential of alterations detected in tumors

Call for papers: Special issue on genomics of infection and immunity

We are now inviting the submission of Research, Method and Software manuscripts. Visit the special issue page to find out more about submitting your article.

Disease Neurogenomics: Special issue

Read our latest collection featuring advances in understanding the impact of genetic and genomic variation on neuronal function, brain wiring and the transition to dysregulation.

Review: Recurrent de novo mutations in neurodevelopmental disorders: properties and clinical implications

Eichler and colleagues discuss advances in our understanding of recurrent de novo mutations and the associated genetics of neurodevelopmental disorders.

Video abstract: A new blood test uses DNA methylation to detect and predict the spread of breast cancer

A study by Widschwendter and colleagues suggests that serum DNAme markers can diagnose fatal breast cancers up to one year in advance of current diagnosis and enable individualized treatment which may even commence before obtaining radiological evidence – see the video abstract for a graphic summary of the paper.

Recent
Most accessed

Content type: Software
| 25 April 2018

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Authors: Francis Blokzijl, Roel Janssen, Ruben van Boxtel and Edwin Cuppen
Content type: Comment
| 24 April 2018

Pathogen detection in the CRISPR–Cas era

Authors: Dipali G. Sashital
Content type: Method
| 19 April 2018

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Authors: Yingleong Chan, Ying Kai Chan, Daniel B. Goodman, Xiaoge Guo, Alejandro Chavez, Elaine T. Lim and George M. Church
Content type: Research
| 17 April 2018

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing

Authors: Tianbao Li, Qi Liu, Nick Garza, Steven Kornblau and Victor X. Jin
Content type: Research
| 16 April 2018

Sensitivity to sequencing depth in single-cell cancer genomics

Authors: João M. Alves and David Posada

Most recent articles RSS

View all articles

Content type: Comment
| 1 April 2016

The virome: a missing component of biological interaction networks in health and disease

Authors: Scott A. Handley
Content type: Research
| 10 May 2016

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Authors: Nadja B. Kristensen, Thomas Bryrup, Kristine H. Allin, Trine Nielsen, Tue H. Hansen and Oluf Pedersen
Content type: Research
| 19 April 2017

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Authors: Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber…
Content type: Review
| 18 August 2017

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

Authors: Ashraful Haque, Jessica Engel, Sarah A. Teichmann and Tapio Lönnberg
Content type: Open debate
| 31 January 2013

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Authors: A Lane Baldwin and Robert Cook-Deegan

Most accessed articles RSS

View all articles

Aims and scope

Genome Medicine publishes research and reviews that describe important advances in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas covered include, but are not limited to: precision medicine, novel methods and software, cancer genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome and systems medicine.

Article collections

Special issue
Disease Neurogenomics
Guest editors: Joseph Buxbaum and Catalina Betancur

Collection
Highlights from infectious disease genomics

Special issue
Genomic technologies: development and clinical application
Guest editor: Stephen Kingsmore

Special issue
Precision cancer medicine
Guest editors: Michael Berger and Eliezer Van Allen

See all article collections

Latest Tweets

From the blog

Celebrating simulation in Saudi: Research abstracts from the 3rd national conference

23 April 2018
Treating depression in Parkinson’s disease

11 April 2018
Parkinson’s disease: the beginning of the third century

09 April 2018

Genome Medicine

Research: Evidence-driven reporting of treatment options in molecular tumor boards

Database: Cancer Genome Interpreter annotates the relevance of tumor alterations

Call for papers: Special issue on genomics of infection and immunity

Disease Neurogenomics: Special issue

Review: Recurrent de novo mutations in neurodevelopmental disorders: properties and clinical implications

Video abstract: A new blood test uses DNA methylation to detect and predict the spread of breast cancer

Articles

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Pathogen detection in the CRISPR–Cas era

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing

Sensitivity to sequencing depth in single-cell cancer genomics

The virome: a missing component of biological interaction networks in health and disease

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Aims and scope

Article collections

Latest Tweets

From the blog

Celebrating simulation in Saudi: Research abstracts from the 3rd national conference

Treating depression in Parkinson’s disease

Parkinson’s disease: the beginning of the third century

Follow

2016 Journal Metrics

Genome Medicine

Contact us