Genome Medicine

Method: RM-seq

A sequencing workflow for comprehensive detection of antibiotic-resistant bacterial populations

Featured Comment: CRISPR/Cas9 and p53

Conti and Di Micco discuss cellular responses to precision genome editing, in light of recent findings

Visualizing cancer genomes

The OncoGenomic Landscapes open-source software can contextualize thousands of cancer genomes in a 2D space

Defining Ebola life cycle host factors

Toward finding new therapeutic strategies, reverse genetics life cycle modelling identifies an essential host pathway

Genomics of infection and immunity

Read the latest additions to our Spring 2018 special issue, guest-edited by Bali Pulendran and Mark Davis

Progress in proteogenomics

This Opinion article describes a recommended framework for mapping genetic mutations to 3D protein structures

Content type: Research
| 28 September 2018

T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

Authors: Erik L. Clarke, A. Jesse Connell, Emmanuelle Six, Nadia A. Kadry, Arwa A. Abbas, Young Hwang, John K. Everett, Casey E. Hofstaedter, Rebecca Marsh, Myriam Armant, Judith Kelsen, Luigi D. Notarangelo, Ronald G. Collman, Salima Hacein-Bey-Abina, Donald B. Kohn, Marina Cavazzana…
Content type: Research
| 28 September 2018

Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder

Authors: Elizabeth A. Normand, Alicia Braxton, Salma Nassef, Patricia A. Ward, Francesco Vetrini, Weimin He, Vipulkumar Patel, Chunjing Qu, Lauren E. Westerfield, Samantha Stover, Avinash V. Dharmadhikari, Donna M. Muzny, Richard A. Gibbs, Hongzheng Dai, Linyan Meng, Xia Wang…
Content type: Review
| 28 September 2018

Advanced model systems and tools for basic and translational human immunology

Authors: Lisa E. Wagar, Robert M. DiFazio and Mark M. Davis
Content type: Editorial
| 26 September 2018

Infection and immunity: insights and therapeutic strategies through genomic analysis of the host, pathogen, and host–pathogen interaction

Authors: Julia Simundza
Content type: Research
| 20 September 2018

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Authors: Cherry S. Leung, Kevin Y. Yang, Xisheng Li, Vicken W. Chan, Manching Ku, Herman Waldmann, Shohei Hori, Jason C. H. Tsang, Yuk Ming Dennis Lo and Kathy O. Lui

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Content type: Comment
| 1 April 2016

The virome: a missing component of biological interaction networks in health and disease

Authors: Scott A. Handley
Content type: Research
| 10 May 2016

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Authors: Nadja B. Kristensen, Thomas Bryrup, Kristine H. Allin, Trine Nielsen, Tue H. Hansen and Oluf Pedersen
Content type: Research
| 19 April 2017

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Authors: Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber…
Content type: Open debate
| 31 January 2013

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Authors: A Lane Baldwin and Robert Cook-Deegan
Content type: Research
| 27 August 2015

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

Authors: Francis Robert, Mathilde Barbeau, Sylvain Éthier, Josée Dostie and Jerry Pelletier

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Focus: the Microbiome

Read the latest Reviews on microbiomes across BMC flagship journals.

The gut microbiome in human immunodeficiency virus infection
Gili Zilberman-Schapira, Niv Zmora, Shlomik Itav, Stavros Bashiardes, Hila Elinav and Eran Elinav
Published in BMC Medicine on: 3 June 2016

The human microbiome in evolution
Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight
Published in BMC Biology on: 27 December2017

The healthy human microbiome
Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower
Published in Genome Medicine on: 27 April 2016

Experimental design and quantitative analysis of microbial community multiomics
Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower Himel Mallick, Siyuan Ma, Eric A. Franzosa, Tommi Vatanen, Xochitl C. Morgan and Curtis Huttenhower
Published in Genome Biology on: 30 November 2017

Aims and scope

Genome Medicine publishes research and reviews that describe important advances in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas covered include, but are not limited to: precision medicine, novel methods and software, cancer genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome and systems medicine.

Article collections

Special issue
Genomics of infection and immunity
Guest editors: Bali Pulendran and Mark Davis

Special issue
Disease Neurogenomics
Guest editors: Joseph Buxbaum and Catalina Betancur

Collection
Highlights from infectious disease genomics

Special issue
Genomic technologies: development and clinical application
Guest editor: Stephen Kingsmore

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Genome Medicine

Method: RM-seq

Featured Comment: CRISPR/Cas9 and p53

Visualizing cancer genomes

Defining Ebola life cycle host factors

Genomics of infection and immunity

Progress in proteogenomics

Articles

T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder

Advanced model systems and tools for basic and translational human immunology

Infection and immunity: insights and therapeutic strategies through genomic analysis of the host, pathogen, and host–pathogen interaction

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

The virome: a missing component of biological interaction networks in health and disease

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

Focus: the Microbiome

Aims and scope

Article collections

Latest Tweets

From the blog

BMC Medicine at ESC Congress 2018

Harness the healing power of electricity

World Thrombosis Day (WTD): impacts of hospitalization, cancer-bearing, and earthquakes

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