Genome Medicine

Method: RM-seq

A sequencing workflow for comprehensive detection of antibiotic-resistant bacterial populations

Featured Comment: CRISPR/Cas9 and p53

Conti and Di Micco discuss cellular responses to precision genome editing, in light of recent findings

Visualizing cancer genomes

The OncoGenomic Landscapes open-source software can contextualize thousands of cancer genomes in a 2D space

Defining Ebola life cycle host factors

Toward finding new therapeutic strategies, reverse genetics life cycle modelling identifies an essential host pathway

Genomics of infection and immunity

Read the latest additions to our Spring 2018 special issue, guest-edited by Bali Pulendran and Mark Davis

Progress in proteogenomics

This Opinion article describes a recommended framework for mapping genetic mutations to 3D protein structures

Content type: Research
| 20 September 2018

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Authors: Cherry S. Leung, Kevin Y. Yang, Xisheng Li, Vicken W. Chan, Manching Ku, Herman Waldmann, Shohei Hori, Jason C. H. Tsang, Yuk Ming Dennis Lo and Kathy O. Lui
Content type: Research
| 14 September 2018

Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

Authors: Alexandra R. Buckley, Trey Ideker, Hannah Carter, Olivier Harismendy and Nicholas J. Schork
Content type: Research
| 4 September 2018

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Authors: Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams and Jane Worthington
Content type: Method
| 31 August 2018

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Authors: Romain Guérillot, Lucy Li, Sarah Baines, Brian Howden, Mark B. Schultz, Torsten Seemann, Ian Monk, Sacha J. Pidot, Wei Gao, Stefano Giulieri, Anders Gonçalves da Silva, Anthony D’Agata, Takehiro Tomita, Anton Y. Peleg, Timothy P. Stinear and Benjamin P. Howden
Content type: Research
| 25 August 2018

Exploring the pre-immune landscape of antigen-specific T cells

Authors: Mikhail V. Pogorelyy, Alla D. Fedorova, James E. McLaren, Kristin Ladell, Dmitri V. Bagaev, Alexey V. Eliseev, Artem I. Mikelov, Anna E. Koneva, Ivan V. Zvyagin, David A. Price, Dmitry M. Chudakov and Mikhail Shugay

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Content type: Comment
| 1 April 2016

The virome: a missing component of biological interaction networks in health and disease

Authors: Scott A. Handley
Content type: Research
| 10 May 2016

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Authors: Nadja B. Kristensen, Thomas Bryrup, Kristine H. Allin, Trine Nielsen, Tue H. Hansen and Oluf Pedersen
Content type: Research
| 19 April 2017

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Authors: Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber…
Content type: Open debate
| 31 January 2013

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Authors: A Lane Baldwin and Robert Cook-Deegan
Content type: Research
| 27 August 2015

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

Authors: Francis Robert, Mathilde Barbeau, Sylvain Éthier, Josée Dostie and Jerry Pelletier

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Focus: Immunology in Health and Disease

Read the latest Reviews on immunology across BMC flagship journals.

Advances in immunotherapy for melanoma
Jason M. Redman, Geoffrey T. Gibney and Michael B. Atkins
Published in BMC Medicine on: 6 February 2016

Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published in BMC Biology on: 29 June 2017

Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
Cornelis J. M. Melief and Jan H. Kessler
Published in Genome Medicine on: 24 May 2017

The MHC locus and genetic susceptibility to autoimmune and infectious diseases
Vasiliki Matzaraki, Vinod Kumar, Cisca Wijmenga and Alexandra Zhernakova
Published in Genome Biology on: 27 April 2017

Aims and scope

Genome Medicine publishes research and reviews that describe important advances in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas covered include, but are not limited to: precision medicine, novel methods and software, cancer genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome and systems medicine.

Article collections

Special issue
Genomics of infection and immunity
Guest editors: Bali Pulendran and Mark Davis

Special issue
Disease Neurogenomics
Guest editors: Joseph Buxbaum and Catalina Betancur

Collection
Highlights from infectious disease genomics

Special issue
Genomic technologies: development and clinical application
Guest editor: Stephen Kingsmore

See all article collections

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From the blog

Big data, big ethics: how to handle research data from medical emergency settings?

13 September 2018
How identical twins are helping us understand epigenetic factors in rheumatoid arthritis

06 September 2018
Adjusting to a new life after forced migration: how are young refugees faring in Australia?

04 September 2018

Genome Medicine

Method: RM-seq

Featured Comment: CRISPR/Cas9 and p53

Visualizing cancer genomes

Defining Ebola life cycle host factors

Genomics of infection and immunity

Progress in proteogenomics

Articles

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Exploring the pre-immune landscape of antigen-specific T cells

The virome: a missing component of biological interaction networks in health and disease

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

Focus: Immunology in Health and Disease

Aims and scope

Article collections

Latest Tweets

From the blog

Big data, big ethics: how to handle research data from medical emergency settings?

How identical twins are helping us understand epigenetic factors in rheumatoid arthritis

Adjusting to a new life after forced migration: how are young refugees faring in Australia?

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