Genome Medicine

Special Issue: Genomics of Infection and Immunity

Read the latest articles in our new special issue, guest-edited by Bali Pulendran and Mark Davis

Call for Papers - Genome Integrity to Cancer: Mechanisms and Translational Opportunities

The Call for Papers is now open for our Fall 2018 special issue, guest-edited by Serena Nik-Zainal

New Software: PanDrugs

A pathway-centric approach to extend anticancer therapeutic options beyond known driver genes

Calling DNA alterations in FFPE tissue

cisCall is a new method for accurate detection of SNV/indels, fusions, and copy-number alterations in FFPE tissue samples

Host genetic variation and its microbiome interactions

Recent research from the Human Microbiome Project pairs deep sequencing of host genomes with body-wide microbiome sequences

Video abstract: A new blood test uses DNA methylation to detect and predict the spread of breast cancer

A study by Widschwendter and colleagues suggests that serum DNAme markers can diagnose fatal breast cancers up to one year in advance of current diagnosis and enable individualized treatment which may even commence before obtaining radiological evidence – see the video abstract for a graphic summary of the paper.

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Most accessed

Content type: Research
| 14 June 2018

KLRD1-expressing natural killer cells predict influenza susceptibility

Authors: Erika Bongen, Francesco Vallania, Paul J. Utz and Purvesh Khatri
Content type: Research
| 8 June 2018

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Authors: Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga and Oscar Harari
Content type: Method
| 7 June 2018

A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing

Authors: Mamoru Kato, Hiromi Nakamura, Momoko Nagai, Takashi Kubo, Asmaa Elzawahry, Yasushi Totoki, Yuko Tanabe, Eisaku Furukawa, Joe Miyamoto, Hiromi Sakamoto, Shingo Matsumoto, Kuniko Sunami, Yasuhito Arai, Yutaka Suzuki, Teruhiko Yoshida, Katsuya Tsuchihara…
Content type: Software
| 31 May 2018

PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data

Authors: Elena Piñeiro-Yáñez, Miguel Reboiro-Jato, Gonzalo Gómez-López, Javier Perales-Patón, Kevin Troulé, José Manuel Rodríguez, Héctor Tejero, Takeshi Shimamura, Pedro Pablo López-Casas, Julián Carretero, Alfonso Valencia, Manuel Hidalgo, Daniel Glez-Peña and Fátima Al-Shahrour
Content type: Research
| 30 May 2018

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

Authors: Jinming Cheng, Dongkai Wei, Yuan Ji, Lingli Chen, Liguang Yang, Guang Li, Leilei Wu, Ting Hou, Lu Xie, Guohui Ding, Hong Li and Yixue Li

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Content type: Comment
| 1 April 2016

The virome: a missing component of biological interaction networks in health and disease

Authors: Scott A. Handley
Content type: Research
| 10 May 2016

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Authors: Nadja B. Kristensen, Thomas Bryrup, Kristine H. Allin, Trine Nielsen, Tue H. Hansen and Oluf Pedersen
Content type: Open debate
| 31 January 2013

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Authors: A Lane Baldwin and Robert Cook-Deegan
Content type: Research
| 27 August 2015

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

Authors: Francis Robert, Mathilde Barbeau, Sylvain Éthier, Josée Dostie and Jerry Pelletier
Content type: Research
| 19 April 2017

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Authors: Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber…

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Aims and scope

Genome Medicine publishes research and reviews that describe important advances in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas covered include, but are not limited to: precision medicine, novel methods and software, cancer genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome and systems medicine.

Article collections

Special issue
Genomics of infection and immunity
Guest editors: Bali Pulendran and Mark Davis

Special issue
Disease Neurogenomics
Guest editors: Joseph Buxbaum and Catalina Betancur

Collection
Highlights from infectious disease genomics

Special issue
Genomic technologies: development and clinical application
Guest editor: Stephen Kingsmore

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Prediction models: how (not) to make them work in clinical medicine

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08 June 2018

Genome Medicine

Special Issue: Genomics of Infection and Immunity

Call for Papers - Genome Integrity to Cancer: Mechanisms and Translational Opportunities

New Software: PanDrugs

Calling DNA alterations in FFPE tissue

Host genetic variation and its microbiome interactions

Video abstract: A new blood test uses DNA methylation to detect and predict the spread of breast cancer

Articles

KLRD1-expressing natural killer cells predict influenza susceptibility

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing

PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

The virome: a missing component of biological interaction networks in health and disease

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis^® compared to Genentech's Herceptin^®

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Aims and scope

Article collections

Latest Tweets

From the blog

Prediction models: how (not) to make them work in clinical medicine

Using social media in medicine to your advantage, with care!

Free Open Access Medical education (FOAM): the new way to keep up-to-date

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