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From genome integrity to cancer

New Research and Comments added to our Fall 2018 special issue - guest-edited by Serena Nik-Zainal

Tumor biology and microbial ecology

A multi-omic analysis of the microbiome associated with mismatch repair status in colorectal cancer

Monitoring hypervirulent pathogens

Siderophore loci inform genomic surveillance efforts for hypervirulent K. pneumoniae

Recent advances in immunotherapies

Bucktrout, Bluestone & Ramsdell cover T cell therapies in infection, autoimmunity, and cancer 

Reviews, Research Highlights and Commentaries

Read authoritative Reviews, Opinions and other content commissioned by the Genome Medicine Editors from leading researchers:


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Focus: Genome Editing

Read the latest Reviews on genome editing across BMC flagship journals.

Genome editing for inborn errors of metabolism: advancing towards the clinic
Jessica L. Schneller, Ciaran M. Lee, Gang Bao and Charles P. Venditti
Published in BMC Medicine on: 27 February 2017

Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
Yuwei Zhu, Fan Zhang and Zhiwei Huang
Published in BMC Biology on: 19 March 2018

Resources for the design of CRISPR gene editing experiments
Daniel B. Graham and David E. Root
Published in Genome Biology on: 27 November 2015

Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Dianne Nicol, Lisa Eckstein, Michael Morrison, Jacob S. Sherkow, Margaret Otlowski, Tess Whitton, Tania Bubela, Kathryn P. Burdon, Don Chalmers, Sarah Chan, Jac Charlesworth, Christine Critchley, Merlin Crossley, Sheryl de Lacey, Joanne L. Dickinson, Alex W. Hewitt, Joanne Kamens, Kazuto Kato, Erika Kleiderman, Satoshi Kodama, John Liddicoat, David A. Mackey, Ainsley J. Newson, Jane Nielsen, Jennifer K. Wagner and Rebekah E. McWhirter
Published in Genome Medicine on: 25 September 2017


Aims and scope

Genome Medicine publishes research and reviews that describe important advances in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas covered include, but are not limited to: precision medicine, novel methods and software, cancer genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome and systems medicine.

Article collections

Special issue
From genome integrity to cancer
Guest editor: Serena Nik-Zainal

Special issue
Genomics of infection and immunity
Guest editors: Bali Pulendran and Mark Davis

Special issue
Disease Neurogenomics
Guest editors: Joseph Buxbaum and Catalina Betancur

Highlights from infectious disease genomics​​​​​​​

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