Table 1 Baseline characteristics among women included in hormone-therapy proteomics project (n = 50 for E+P and for E-alone trials)
From: Postmenopausal estrogen and progestin effects on the serum proteome
| Â | E+P | E-alone | Â | ||
|---|---|---|---|---|---|
| Â | Number | % | Number | % | Pvaluea |
Age group at screening, years | Â | Â | Â | Â | 0.20 |
   50-59 | 17 | 34.0 | 25 | 50.0 |  |
   60-69 | 21 | 42.0 | 13 | 26.0 |  |
   70-79 | 12 | 24.0 | 12 | 24.0 |  |
Minority race/ethnicity | 3 | 6.0 | 8 | 16.0 | 0.20 |
Postmenopausal hormone therapy use | Â | Â | Â | Â | 0.69 |
   Never used | 31 | 62.0 | 26 | 52.0 |  |
   Past user | 15 | 30.0 | 19 | 38.0 |  |
   Current user (3-month 'wash out' before enrollment) | 4 | 8.0 | 5 | 10.0 |  |
Smoking | Â | Â | Â | Â | 0.50 |
   Never | 34 | 69.4 | 29 | 58.0 |  |
   Past | 14 | 28.6 | 19 | 38.0 |  |
   Current | 1 | 2.0 | 2 | 4.0 |  |
Parity | Â | Â | Â | Â | 0.74 |
   Never pregnant/no term pregnancy | 6 | 12.0 | 4 | 8.0 |  |
   ≥ 1term pregnancy | 44 | 88.0 | 46 | 92.0 |  |
Age at first birth, years | Â | Â | Â | Â | 0.38 |
   <20 | 8 | 21.1 | 15 | 34.1 |  |
   20-29 | 29 | 76.3 | 27 | 61.4 |  |
   30+ | 1 | 2.6 | 2 | 4.5 |  |
Treated diabetes | 2 | 4.0 | 7 | 14.0 | 0.16 |
Treated for hypertension or BP ≥ 140/90 | 15 | 31.9 | 17 | 37.0 | 0.67 |
History of high cholesterol requiring pills | 2 | 4.3 | 2 | 4.5 | >0.99 |
Statin use at baseline | 0 | 0.0 | 2 | 4.0 | 0.49 |
Aspirin (≥ 80 mg) use at baseline | 8 | 16.0 | 8 | 16.0 | >0.99 |
History of MI | 1 | 2.0 | 0 | 0.0 | >0.99 |
History of angina | 1 | 2.0 | 3 | 6.0 | 0.62 |
History of CABG/PTCA | 1 | 2.0 | 0 | 0.0 | >0.99 |
History of DVT or PE | 1 | 2.0 | 0 | 0.0 | >0.99 |
Family history of breast cancer (female) | 6 | 13.0 | 7 | 14.6 | >0.99 |
History of fracture on or after age 55 | 3 | 8.3 | 1 | 3.1 | 0.62 |
Gail Model Five Year Risk of Breast Cancer | Â | Â | Â | Â | 0.26 |
   <1 | 7 | 14.0 | 10 | 20.0 |  |
   1 - <2 | 31 | 62.0 | 34 | 68.0 |  |
   2 - <5 | 12 | 24.0 | 6 | 12.0 |  |
Number of falls in last 12 months | Â | Â | Â | Â | 0.97 |
   None | 31 | 66.0 | 30 | 69.8 |  |
   1 time | 9 | 19.1 | 7 | 16.3 |  |
   2 times | 6 | 12.8 | 6 | 14.0 |  |
   3 or more times | 1 | 2.1 | 0 | 0.0 |  |
| Â | Mean | SD | Mean | SD | P value b |
Age at screening, years | 63.2 | 7.2 | 61.4 | 7.9 | 0.24 |
Body-mass index (BMI), kg/m2 | 28.8 | 6.0 | 31.1 | 6.1 | 0.05 |