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Table 3 Difference in Year 1 from baseline concentration ratios (E+P minus E-Alone) for all proteins with difference of P < 0.05

From: Postmenopausal estrogen and progestin effects on the serum proteome

Protein Description Difference of log2 ratios (year 1 relative to baseline): E+P minus E-alone P-Diff FDR
LUM Lumican -0.219 0.00141 0.317
IGFBP1 Insulin-like growth factor-binding protein 1 -0.742 0.00227 0.317
PGLYRP1 Peptidoglycan recognition protein 0.377 0.00259 0.317
NOTCH2 Neurogenic locus notch homologue protein 2 -0.723 0.00426 0.33
ACTB Actin cytoplasmic 1 0.667 0.00527 0.33
LYVE1 Lymphatic vessel endothelial hyaluronic acid receptor 1 -0.217 0.00538 0.33
AZGP1 α2-Glycoprotein 1 zinc 0.496 0.00776 0.408
ICAM1 Intercellular adhesion molecule 1 -0.158 0.0126 0.511
SPARCL1 SPARC-like protein 1 -0.268 0.0138 0.511
COL1A1 Collagen α-1(I) chain -0.321 0.015 0.511
A1BG Á1B-glycoprotein -0.099 0.0153 0.511
SEPP1 Selenoprotein P 0.756 0.0181 0.549
F5 Coagulation factor V 0.301 0.0194 0.549
CFL1 Cofilin-1 0.597 0.023 0.549
C6orf115 Similar to protein C6ORF115 1.070 0.0233 0.549
MMP2 72-kDa type IV collagenase 1.190 0.0246 0.549
HRG Histidine-rich glycoprotein -0.136 0.0282 0.549
ABCA9 ATP-binding cassette subfamily A member 9 3.280 0.0284 0.549
MMRN1 Multimerin-1 0.691 0.0293 0.549
AFM Afamin -0.120 0.0298 0.549
MCAM Cell-surface glycoprotein MUC18 -0.357 0.0409 0.614
NOV Protein NOV Homologue -0.415 0.0409 0.614
TFF2 Trefoil factor 2 -1.920 0.0412 0.614
ECM1 Extracellular matrix protein 1 -0.184 0.0412 0.614
IGFBP4 Insulin-like growth factor-binding protein 4 -0.332 0.0442 0.614
CFB Complement factor B -0.073 0.0444 0.614
  1. P-Diff = significance level for test of equality of protein-concentration ratios for E+P and E-alone; FDR = estimated false discovery rate for this test.