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Table 3 Difference in Year 1 from baseline concentration ratios (E+P minus E-Alone) for all proteins with difference of P < 0.05

From: Postmenopausal estrogen and progestin effects on the serum proteome

Protein

Description

Difference of log2 ratios (year 1 relative to baseline): E+P minus E-alone

P-Diff

FDR

LUM

Lumican

-0.219

0.00141

0.317

IGFBP1

Insulin-like growth factor-binding protein 1

-0.742

0.00227

0.317

PGLYRP1

Peptidoglycan recognition protein

0.377

0.00259

0.317

NOTCH2

Neurogenic locus notch homologue protein 2

-0.723

0.00426

0.33

ACTB

Actin cytoplasmic 1

0.667

0.00527

0.33

LYVE1

Lymphatic vessel endothelial hyaluronic acid receptor 1

-0.217

0.00538

0.33

AZGP1

α2-Glycoprotein 1 zinc

0.496

0.00776

0.408

ICAM1

Intercellular adhesion molecule 1

-0.158

0.0126

0.511

SPARCL1

SPARC-like protein 1

-0.268

0.0138

0.511

COL1A1

Collagen α-1(I) chain

-0.321

0.015

0.511

A1BG

Á1B-glycoprotein

-0.099

0.0153

0.511

SEPP1

Selenoprotein P

0.756

0.0181

0.549

F5

Coagulation factor V

0.301

0.0194

0.549

CFL1

Cofilin-1

0.597

0.023

0.549

C6orf115

Similar to protein C6ORF115

1.070

0.0233

0.549

MMP2

72-kDa type IV collagenase

1.190

0.0246

0.549

HRG

Histidine-rich glycoprotein

-0.136

0.0282

0.549

ABCA9

ATP-binding cassette subfamily A member 9

3.280

0.0284

0.549

MMRN1

Multimerin-1

0.691

0.0293

0.549

AFM

Afamin

-0.120

0.0298

0.549

MCAM

Cell-surface glycoprotein MUC18

-0.357

0.0409

0.614

NOV

Protein NOV Homologue

-0.415

0.0409

0.614

TFF2

Trefoil factor 2

-1.920

0.0412

0.614

ECM1

Extracellular matrix protein 1

-0.184

0.0412

0.614

IGFBP4

Insulin-like growth factor-binding protein 4

-0.332

0.0442

0.614

CFB

Complement factor B

-0.073

0.0444

0.614

  1. P-Diff = significance level for test of equality of protein-concentration ratios for E+P and E-alone; FDR = estimated false discovery rate for this test.