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Table 1 Pharmacogenomics information on the top ten selling drugs in the world

From: Pharmacogenomics and personalized medicine: lost in translation?

Generic name Therapeutic class Indications Genetic influence? Drug-induced phenotype Type of studies Genetic variant
Atorvastatin Statins Dyslipidemia Yes Myopathy GWAS and candidate gene SLCO1B1 (drug transporter)
Clopidogrel Anti-platelet agent Atherothombosis Yes Resistance to treatment GWAS and candidate gene CYP2C19 (hepatic enzyme)
Esomeprazole Proton pump inhibitor Gastric ulcer Yes Drug efficacy Candidate gene CYP2C19 (hepatic enzyme)
Fluticasone/Salmeterol Bronchodilator Asthma Possible Drug efficacy Candidate gene Beta-2 adrenoreceptor
Etanercept TNF antagonist Rheumatoid arthritis Possible Drug efficacy GWAS and candidate gene MAFB
Olanzapine Psychotropes Mental disorders Yes Drug efficacy GWAS and candidate gene ANKS1B; CNTNAP5
Risperidone Psychotropes Mental disorders Yes Drug efficacy GWAS and candidate gene ANKS1B; CNTNAP5
Darbopoetin Erythropoetin Anemia ? - - -
Venlafaxin Anti-depressant Depression Possible Drug efficacy Candidate gene CYP2D6; dopamine/serotonin transporter
Amlodipine Anti-hypertensive Hypertensive ? Drug efficacy Candidate gene NOS1AP