Table 1 Pharmacogenomics information on the top ten selling drugs in the world
From: Pharmacogenomics and personalized medicine: lost in translation?
Generic name | Therapeutic class | Indications | Genetic influence? | Drug-induced phenotype | Type of studies | Genetic variant |
|---|---|---|---|---|---|---|
Atorvastatin | Statins | Dyslipidemia | Yes | Myopathy | GWAS and candidate gene | SLCO1B1 (drug transporter) |
Clopidogrel | Anti-platelet agent | Atherothombosis | Yes | Resistance to treatment | GWAS and candidate gene | CYP2C19 (hepatic enzyme) |
Esomeprazole | Proton pump inhibitor | Gastric ulcer | Yes | Drug efficacy | Candidate gene | CYP2C19 (hepatic enzyme) |
Fluticasone/Salmeterol | Bronchodilator | Asthma | Possible | Drug efficacy | Candidate gene | Beta-2 adrenoreceptor |
Etanercept | TNF antagonist | Rheumatoid arthritis | Possible | Drug efficacy | GWAS and candidate gene | MAFB |
Olanzapine | Psychotropes | Mental disorders | Yes | Drug efficacy | GWAS and candidate gene | ANKS1B; CNTNAP5 |
Risperidone | Psychotropes | Mental disorders | Yes | Drug efficacy | GWAS and candidate gene | ANKS1B; CNTNAP5 |
Darbopoetin | Erythropoetin | Anemia | ? | - | - | - |
Venlafaxin | Anti-depressant | Depression | Possible | Drug efficacy | Candidate gene | CYP2D6; dopamine/serotonin transporter |
Amlodipine | Anti-hypertensive | Hypertensive | ? | Drug efficacy | Candidate gene | NOS1AP |