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Table 2 Relationship between clinical and biochemical characteristics and histological groups in infants with biliary atresia

From: Staging of biliary atresia at diagnosis by molecular profiling of the liver

Patient characteristic Inflammatory subtype, N = 14 Fibrosing subtype, N = 17 Total, N = 31a P-valueb
Sex, N (%)     
   Female 5 (36) 6 (35) 11 (35) 1.0
   Male 9 (64) 11 (65) 20 (65)  
Race, N (%)     
   White 11 (79) 16 (94) 27 (87) 1.0
   Black 0 (0) 0 (0) 0 (0) 1.0
   Asian 2 (14) 1 (6) 3 (10) 1.0
   Other 1 (7) 0 (0) 1 (3) 1.0
Ethnicity, N (%)     
   Hispanic 1 (7) 2 (12) 3 (10) 1.0
   Nonhispanic 13 (93) 15 (88) 28 (90)  
Age in days, median (25-75%) 63 (55-65) 66 (51-77) 63 (51-73) 0.3
Clinical type     
   BASM N (%) 1 (7) 1 (6) 2 (7) 1.0
   Perinatal N (%) 13 (93) 16 (94) 29 (93)  
Mean CB at diagnosisc 5.1 ± 1.6 5.8 ± 2.5 5.6 ± 2.2 0.5
Mean ALT at diagnosisc 196 ± 150 192 ± 120 194 ± 136 1.0
Mean CB at 3 months after HPEc 2.3 ± 3.7 3.0 ± 3.5 2.6 ± 3.6 0.7
Weight Z-score at 6 months after HPEc -1.1 ± 0.9 -1.8 ± 1.9 -1.4 ± 1.4 0.3
Presence of cholangitis, N (%) 5 (56) 10 (59) 15 (58) 1.0
Presence of ascites, N (%) 4 (36) 9 (53) 13 (47) 0.7
  1. aSixteen subjects from the cohort of 47 patients are not included because the differences in histological scores for inflammation and fibrosis were zero. bP-values denote levels of statistical differences between inflammation and fibrosis groups. cMean ± standard deviation. ALT, alanine aminotransferases; BASM, biliary atresia splenic malformation (polysplenia or asplenia); CB, conjugated bilirubin; HPE, hepatoportoenterostomy.