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Table 2 Proteins having some evidence (P < 0.05) of difference in concentration between stroke cases and controls

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

Protein

Description

Log(base2) case vs control ratio

P-valuea

FDRa

APOA2

Apolipoprotein A-II

-0.120

2.71e-05

0.00991

PPIA

Peptidyl-prolyl cis-trans isomerase A

0.194

7.68e-05

0.0141

IGFBP4

Insulin-like growth factor-binding protein 4

0.409

0.000320

0.0391

F2

Prothrombin (fragment)

-0.0732

0.000702

0.0642

IGF2

Isoform 1 of insulin-like growth factor II

-0.0694

0.00225

0.138

C6

Complement component 6 precursor

-0.140

0.00227

0.138

LILRA3

Leukocyte immunoglobulin-like receptor subfamily a member 3

0.316

0.00341

0.177

HPX

Hemopexin

-0.0448

0.00407

0.177

IGFBP6

Insulin-like growth factor-binding protein 6

0.667

0.00435

0.177

LOC650157

Similar to peptidyl-pro cis trans isomerase

0.237

0.00510

0.187

IGFBP2

Insulin-like growth factor-binding protein 2

0.480

0.00609

0.189

GC

Vitamin D-binding protein

-0.0532

0.00699

0.189

CADM1

Isoform 1 of cell adhesion molecule 1

-0.199

0.00762

0.189

PIN1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

0.190

0.00767

0.189

CTSD

Cathepsin D

0.490

0.00776

0.189

COL1A1

Collagen alpha-1(I) chain

0.195

0.00826

0.189

F13B

Coagulation factor XIII b chain

0.121

0.00903

0.194

MANSC1

MANSC domain-containing protein 1

-0.962

0.0102

0.207

COL6A3

Isoform 1 of collagen alpha-3(VI) chain

0.828

0.0109

0.210

GRN

cDNA FLJ13286 fis clone OVARC1001154 highly similar to Homo sapiens clone 24720 epithelin 1 and 2 mRNA

0.316

0.0130

0.238

RNASE1

Ribonuclease pancreatic

0.582

0.0143

0.243

MTPN

Myotrophin

0.249

0.0146

0.243

GLIPR2

Golgi-associated plant pathogenesis-related protein 1

0.623

0.0168

0.265

ADAMTSL2

ADAMTS-like protein 2

0.205

0.0184

0.265

ITIH4

Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4

-0.238

0.0187

0.265

HLA-DRB5b

Non-secretory ribonuclease

0.784

0.0188

0.265

KLKB1

Plasma kallikrein

-0.115

0.0202

0.270

CD59

CD59 glycoprotein

0.866

0.0208

0.270

CD14

Monocyte differentiation antigen CD14

0.104

0.0214

0.270

CSF1R

Macrophage colony-stimulating factor 1 receptor

0.259

0.0223

0.272

GRB2

Isoform 1 of growth factor receptor-bound protein 2

1.58

0.0235

0.278

CD5L

CD5 antigen-like

0.147

0.0253

0.289

B2M

Beta-2-microglobulin

0.0728

0.0280

0.310

SERPINC1

Antithrombin-III

-0.0631

0.0312

0.325

FCN3

Isoform 1 of ficolin-3

0.132

0.0323

0.325

HGFAC

Hepatocyte growth factor activator

-0.592

0.0324

0.325

RBP4

Retinol-binding protein 4

0.0478

0.0346

0.325

CFHR5

Complement factor H-related 5

-0.0800

0.0348

0.325

PRDX2

Peroxiredoxin-2

-0.533

0.0361

0.325

C8A

Complement component C8 alpha chain

-0.179

0.0373

0.325

ADAMTSL4

Isoform 1 of ADAMTS-like protein 4

-0.130

0.0373

0.325

QSOX1

Isoform 1 of sulfhydryl oxidase 1

0.370

0.0376

0.325

CPB2

Isoform 1 of carboxypeptidase B2

-0.228

0.0381

0.325

FETUB

Fetuin-B

0.0662

0.0410

0.332

PPIF

Peptidyl-prolyl cis-trans isomerase mitochondrial

0.318

0.0414

0.332

LCN2

Neutrophil gelatinase-associated lipocalin

0.172

0.0417

0.332

DSC1

Isoform 1B of desmocollin-1

-0.265

0.0438

0.341

  1. aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate. bThe DRB5 protein group also includes ZNF749, LOC100133811, LOC100133484, LOC100133661, HLA-DRB1, HLA-DRB4, RNASE2, and HLA-DRB3.
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Genome Medicine

ISSN: 1756-994X

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