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Table 2 Proteins having some evidence (P < 0.05) of difference in concentration between stroke cases and controls

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

Protein Description Log(base2) case vs control ratio P-valuea FDRa
APOA2 Apolipoprotein A-II -0.120 2.71e-05 0.00991
PPIA Peptidyl-prolyl cis-trans isomerase A 0.194 7.68e-05 0.0141
IGFBP4 Insulin-like growth factor-binding protein 4 0.409 0.000320 0.0391
F2 Prothrombin (fragment) -0.0732 0.000702 0.0642
IGF2 Isoform 1 of insulin-like growth factor II -0.0694 0.00225 0.138
C6 Complement component 6 precursor -0.140 0.00227 0.138
LILRA3 Leukocyte immunoglobulin-like receptor subfamily a member 3 0.316 0.00341 0.177
HPX Hemopexin -0.0448 0.00407 0.177
IGFBP6 Insulin-like growth factor-binding protein 6 0.667 0.00435 0.177
LOC650157 Similar to peptidyl-pro cis trans isomerase 0.237 0.00510 0.187
IGFBP2 Insulin-like growth factor-binding protein 2 0.480 0.00609 0.189
GC Vitamin D-binding protein -0.0532 0.00699 0.189
CADM1 Isoform 1 of cell adhesion molecule 1 -0.199 0.00762 0.189
PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0.190 0.00767 0.189
CTSD Cathepsin D 0.490 0.00776 0.189
COL1A1 Collagen alpha-1(I) chain 0.195 0.00826 0.189
F13B Coagulation factor XIII b chain 0.121 0.00903 0.194
MANSC1 MANSC domain-containing protein 1 -0.962 0.0102 0.207
COL6A3 Isoform 1 of collagen alpha-3(VI) chain 0.828 0.0109 0.210
GRN cDNA FLJ13286 fis clone OVARC1001154 highly similar to Homo sapiens clone 24720 epithelin 1 and 2 mRNA 0.316 0.0130 0.238
RNASE1 Ribonuclease pancreatic 0.582 0.0143 0.243
MTPN Myotrophin 0.249 0.0146 0.243
GLIPR2 Golgi-associated plant pathogenesis-related protein 1 0.623 0.0168 0.265
ADAMTSL2 ADAMTS-like protein 2 0.205 0.0184 0.265
ITIH4 Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4 -0.238 0.0187 0.265
HLA-DRB5b Non-secretory ribonuclease 0.784 0.0188 0.265
KLKB1 Plasma kallikrein -0.115 0.0202 0.270
CD59 CD59 glycoprotein 0.866 0.0208 0.270
CD14 Monocyte differentiation antigen CD14 0.104 0.0214 0.270
CSF1R Macrophage colony-stimulating factor 1 receptor 0.259 0.0223 0.272
GRB2 Isoform 1 of growth factor receptor-bound protein 2 1.58 0.0235 0.278
CD5L CD5 antigen-like 0.147 0.0253 0.289
B2M Beta-2-microglobulin 0.0728 0.0280 0.310
SERPINC1 Antithrombin-III -0.0631 0.0312 0.325
FCN3 Isoform 1 of ficolin-3 0.132 0.0323 0.325
HGFAC Hepatocyte growth factor activator -0.592 0.0324 0.325
RBP4 Retinol-binding protein 4 0.0478 0.0346 0.325
CFHR5 Complement factor H-related 5 -0.0800 0.0348 0.325
PRDX2 Peroxiredoxin-2 -0.533 0.0361 0.325
C8A Complement component C8 alpha chain -0.179 0.0373 0.325
ADAMTSL4 Isoform 1 of ADAMTS-like protein 4 -0.130 0.0373 0.325
QSOX1 Isoform 1 of sulfhydryl oxidase 1 0.370 0.0376 0.325
CPB2 Isoform 1 of carboxypeptidase B2 -0.228 0.0381 0.325
FETUB Fetuin-B 0.0662 0.0410 0.332
PPIF Peptidyl-prolyl cis-trans isomerase mitochondrial 0.318 0.0414 0.332
LCN2 Neutrophil gelatinase-associated lipocalin 0.172 0.0417 0.332
DSC1 Isoform 1B of desmocollin-1 -0.265 0.0438 0.341
  1. aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate. bThe DRB5 protein group also includes ZNF749, LOC100133811, LOC100133484, LOC100133661, HLA-DRB1, HLA-DRB4, RNASE2, and HLA-DRB3.