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Table 2 Genes and their polymorphisms associated with ischemic stroke in GWASs

From: Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned

System Gene Polymorphism References
Hemostasis Factor II (prothrombin) (+176930) c.20210G > A [39, 4143]
  Factor V (Leiden) (*612309) p.Arg506Gln [3340]
  Factor XIII (+134570) p.Val34Leu [39, 44, 45]
Renin-angiotensin system ACE (+106180) Insertion/deletion [40, 4851]
  AT1R (*106165) c.1166A > C [5255]
Nitric-oxide-synthase system eNOS (+163729) p.Glu298Asp [5658]
Homocysteine metabolism MTHFR (*607093) c.677C > T and c.1298A > C [43, 5961]
Lipid metabolism APOE (+107741) ε4, ε3, ε2 [40, 46, 6266]
  1. ACE, angiotensin converting enzyme; APOE, apolipoprotein E; AT1R, angiotensin-receptor; eNOS, endothelial nitric oxide synthase; MTHFR, 5,10-methylenetetrahydrofolate reductase.