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Table 1 AUC and effect estimates of susceptibility variants for the prediction of three diseases

From: Genome-based prediction of common diseases: methodological considerations for future research

Disease Coronary heart disease Systemic lupus erythematosus Hypertriglyceridemia
AUC* 0.55 0.67 0.80
Reference [35] [28] [12]
Genes and effect estimates       
  AGT 1.28 (1.02, 1.61) HLA 2.36 (2.11, 2.64) APOA5 7.36 (3.98, 13.6)
  ACE 1.18 (0.97, 1.44) ITGAM 1.62 (1.47,1.78) APOA5 5.57 (3.13, 9.90)
  AGTR1 1.21 (1.00, 1.45) IRF5/TNPO3 1.54 (1.40, 1.70) TBL2 2.81 (1.46, 5.24)
  CYP11B2 1.22 (1.01, 1.48) KIAA1542 0.78 (0.73, 0.85) APOE 2.14 (1.31, 3.49)
  ADD1 1.22 (1.01, 1.47) PXK 1.25 (1.16, 1.35) GCKR 2.11 (1.21, 3.67)
  GNB3 0.72 (0.52, 1.01) rs10798269 0.82 (0.76, 0.88) GALNT2 2.10 (1.15, 3.81)
      TRIB1 2.02 (1.24, 3.30)
  1. *AUC, area under the receiver operating characteristic curve. Values are hazard ratios [35] or odds ratios with 95% confidence intervals. The original paper mentions several polymorphisms per gene and that one for each gene was included to assess the combined predictive value of six variants. The polymorphisms that had the highest odds ratios are reported here.