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Table 4 Classification results using different genetic models

From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

  Classification Classification P-Hat (quantiles, case versus control)
Genetic model sensitivity specificity 25% 50% 75%
Discovery dataset (N = 8,844)      
   12 Genesa 35.1% 93.5% 0.23 0.07 0.38 0.13 0.59 0.27
   350 Genesb 79.9% 95.8% 0.65 0.00 0.90 0.01 0.99 0.06
Validation dataset (N = 3,606)      
   12 Genesa 54.3% 74.0% 0.36 0.30 0.53 0.36 0.63 0.51
   350 Genesb 62.3% 75.9% 0.41 0.19 0.59 0.32 0.74 0.49
  1. aThe 12-gene set includes HLA-DRB1 and 11 additional validated susceptibility genes. bThe 350-gene set includes HLA-DRB1 and 349 additional genes identified in the genetic profile.