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Table 4 Classification results using different genetic models

From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

 

Classification

Classification

P-Hat (quantiles, case versus control)

Genetic model

sensitivity

specificity

25%

50%

75%

Discovery dataset (N = 8,844)

     

   12 Genesa

35.1%

93.5%

0.23 0.07

0.38 0.13

0.59 0.27

   350 Genesb

79.9%

95.8%

0.65 0.00

0.90 0.01

0.99 0.06

Validation dataset (N = 3,606)

     

   12 Genesa

54.3%

74.0%

0.36 0.30

0.53 0.36

0.63 0.51

   350 Genesb

62.3%

75.9%

0.41 0.19

0.59 0.32

0.74 0.49

  1. aThe 12-gene set includes HLA-DRB1 and 11 additional validated susceptibility genes. bThe 350-gene set includes HLA-DRB1 and 349 additional genes identified in the genetic profile.